Scientific Production

List of scientific articles published in extenso in peer-reviewed journals
  1. Crisafulli S, Boccanegra B, Carollo M, Bottani E, Mantuano P, Trifirò G, De Luca A. Myasthenia Gravis Treatment: From Old Drugs to Innovative Therapies with a Glimpse into the Future. CNS Drugs. 2024 Jan;38(1):15-32. doi: 10.1007/s40263-023-01059-8.
  2. Boccanegra B, Mantuano P, Conte E, Cerchiara AG, Tulimiero L, Quarta R, Caputo E, Sanarica F, Forino M, Spadotto V, Cappellari O, Fossati G, Steinkühler C, De Luca A. LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model. Dis Model Mech. 2023 Jul 1;16(7):dmm049930. doi: 10.1242/dmm.049930
  3. Boccanegra B*, Cappellari O*, Mantuano P*, Trisciuzzi D, Mele A, Tulimiero L, De Bellis M, Cirmi S, Sanarica F, Cerchiara AG, Conte E, Meanti R, Rizzi L, Bresciani E, Denoyelle S, Fehrentz J-A, Cruciani G, Nicolotti O, Liantonio A, Torsello A, De Luca A. Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy. Front Immunol. 2023 Apr 12; 14:1119888. doi: 10.3389/fimmu.2023.111988 [*equal contribution]
  4. Mele A*, Mantuano P*, Boccanegra B, Conte E, Liantonio A, De Luca A. Preclinical Ultrasonography in Rodent Models of Neuromuscular Disorders: The State of the Art for Diagnostic and Therapeutic Applications. Int J Mol Sci. 2023 Special Issue: "Advances in Animal Models in Biomedical Research". Mar 04; 24(5), 4976. doi: 10.3390/ijms24054976 [*equal contribution]
  5. Mantuano P*, Boccanegra B*, Bianchini G, Cappellari O, Tulimiero L, Conte E, Cirmi S, Sanarica F, De Bellis M, Mele A, Liantonio A, Allegretti M, Aramini A, De Luca A. Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia. Nutrients. 2023 Jan 09; 15(2), 330. doi: 10.3390/nu15020330 [*equal contribution]
  6. Aartsma-Rus A, van Putten M, Mantuano P, De Luca A. On the use of D2.B10-Dmdmdx/J (D2.mdx) versus C57BL/10ScSn-Dmdmdx/J (mdx) mouse models for preclinical studies on Duchenne muscular dystrophy: A cautionary note from members of the TREAT-NMD Advisory Committee on Therapeutics. J Neuromusc Dis. 2022 Oct 31. doi: 10.3233/JND-221547
  7. Mantuano P*, Boccanegra B*, Conte E, De Bellis M, Cirmi S, Sanarica F, Cappellari O, Arduino I, Cutrignelli A, Lopedota AA, Mele A, Denora N, De Luca A. β-Dystroglycan Restoration and Pathology Progression in the Dystrophic mdx Mouse: Outcome and Implication of a Clinically Oriented Study with a Novel Oral Dasatinib Formulation. Biomolecules. 2021 Nov 22;11(11):1742. doi: 10.3390/biom11111742 [*equal contribution]
  8. Conte E, Imbrici P, Mantuano P, Coppola MA, Camerino GM, De Luca A, Liantonio A. Alteration of STIM1/Orai1-Mediated SOCE in Skeletal Muscle: Impact in Genetic Muscle Diseases and Beyond. Cells. 2021 Oct 12;10(10):2722. Review. doi: 10.3390/cells10102722
  9. Mantuano P*, Boccanegra B*, Bianchini G, Conte E, De Bellis M, Sanarica F, Camerino GM, Pierno S, Cappellari O, Allegretti M, Aramini A, De Luca A. BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading. Pharmacol Res. 2021 Sep;171:105798. doi: 10.1016/j.phrs.2021.105798 [*equal contribution]
  10. Rossi R, Falzarano MS, Osman H, Armaroli A, Scotton C, Mantuano P, Boccanegra B, Cappellari O, Schwartz E, Yuryev A, Mercuri E, Bertini E, D’Amico A, Mora M, Johansson C, Al-Khalili Szigyarto C, De Luca A, Ferlini A. Circadian genes as exploratory biomarkers in DMD: results from both the mdx mouse model and patients. Front Physiol. 2021 Jul 8;12:678974. doi: 10.3389/fphys.2021.678974 
  11. Mele A*, Mantuano P*, Fonzino A, Rana F, Capogrosso RF, Sanarica F, Rolland JF, Cappellari O, De Luca A. Ultrasonography validation for early alteration of diaphragm echodensity and function in the mdx mouse model of Duchenne muscular dystrophy. PLoS One. 2021 Jan 12; 12;16(1):e0245397. doi: 10.1371/journal.pone.0245397 [*equal contribution]
  12. Mantuano P*, Bianchini G*, Cappellari O, Boccanegra B, Conte E, Sanarica F, Mele A, Camerino GM, Brandolini L, Allegretti M, De Bellis M, Aramini A, De Luca A. Ergogenic Effect of BCAAs and L-Alanine Supplementation: Proof-of-Concept Study in a Murine Model of Physiological Exercise. Nutrients. 2020 Jul 30; 12(8):E2295. doi: 10.3390/nu12082295 [*equal contribution]
  13. Cappellari O*, Mantuano P*, De Luca A. “The Social Network” and Muscular Dystrophies: The Lesson Learnt About the Niche Environment as a Target for Therapeutic Strategies. Cells. 2020 Jul 9; 9, 1659. Review. doi: 10.3390/cells9071659 [*equal contribution]
  14. Vita GL, Aguennouz M, Sframeli M, Sanarica F, Mantuano P, Oteri R, Polito F, Licata N, Romeo S, Distefano MG, La Rosa M, Bonanno C, Nicocia G, Vita G, De Luca A, Messina S. Effect of exercise on telomere length and telomere proteins expression in mdx mice. Mol Cell Biochem. 2020 Jul; 470 (1-2): 189-197. doi: 10.1007/s11010-020-03761-3
  15. Sanarica F, Mantuano P, Conte E, Cozzoli A, Capogrosso RF, Giustino A, Cutrignelli A, Cappellari O, Rolland JF, De Bellis M, Denora N, Camerino GM, De Luca A. Proof-of-concept validation of the mechanism of action of Src tyrosine kinase inhibitors in dystrophic mdx mouse muscle: in vivo and in vitro studies. Pharmacol Res. 2019 Jul; 145:104260. doi: 10.1016/j.phrs.2019.104260
  16. Cutrignelli A, Sanarica F, Lopalco A, Lopedota A, Laquintana V, Franco M, Boccanegra B, Mantuano P, De Luca A, Denora N. Dasatinib/HP-β-CD inclusion complex based aqueous formulation as a promising tool for the treatment of paediatric neuromuscular disorders. Int J Mol Sci. 2019 Jan 30; 20(3). doi: 10.3390/ijms20030591
  17. Mele A*, Mantuano P*, De Bellis M, Rana F, Sanarica F, Conte E, Morgese MG, Bove M, Rolland JF, Capogrosso RF, Pierno S, Camerino GM, Trabace L, De Luca A. A long-term treatment with taurine prevents cardiac dysfunction in mdx mice. Transl Res. 2019 Feb; 204:82-99. doi: 10.1016/j.trsl.2018.09.004 [*equal contribution]. Erratum in Transl Res. 2020; 223:107
  18. Gamberi T, Fiaschi T, Valocchia E, Modesti A, Mantuano P, Rolland JF, Sanarica F, De Luca A, Magherini F. Data on protein abundance alteration induced by chronic exercise in mdx mice model of Duchenne muscular dystrophy and potential modulation by apocynin and taurine. Data Brief. 2018 Mar; 18:555-575. Data Article. doi: 10.1016/j.dib.2018.03.037
  19. Mantuano P, Sanarica F, Conte E, Morgese MG, Capogrosso RF, Cozzoli A, Fonzino A, Quaranta A, Rolland JF, De Bellis M, Camerino GM, Trabace L, De Luca A. Effect of a long-term treatment with metformin in dystrophic mdx mice: a reconsideration of its potential clinical interest in Duchenne muscular dystrophy. Biochem Pharmacol. 2018 Aug; 154: 89-103. doi: 10.1016/j.bcp.2018.04.022
  20. Capogrosso RF*, Mantuano P*, Uaesoontrachoon K*, Cozzoli A*, Giustino A, Dow T, Srinivassane S, Filipovic M, Bell C, Vandermeulen J, Massari AM, De Bellis M, Conte E, Pierno S, Camerino GM, Liantonio A, Nagaraju K, De Luca A. Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. FASEB J. 2018 Feb; 32 (2), 1025-1043. doi: 10.1096/fj.201700182RRR [*equal contribution]
  21. Gamberi T, Fiaschi T, Valocchia E, Modesti A, Mantuano P, Rolland JF, Sanarica F, De Luca A, Magherini F. Proteome analysis in dystrophic mdx mouse muscle reveals a drastic alteration of key metabolic and contractile proteins after chronic exercise and the potential modulation by anti-oxidant compounds. J Proteomics. 2018 Jan 6; 170: 43-58. doi: 10.1016/j.jprot.2017.09.009
  22. Capogrosso RF, Mantuano P, Cozzoli A, Sanarica F, Massari AM, Conte E, Fonzino A, Giustino A, Rolland JF, Quaranta A, De Bellis M, Camerino GM, Grange RW, De Luca A. Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end-points. J Appl Physiol (1985). 2017 Apr 1; 122(4): 828-43. doi: 10.1152/japplphysiol.00776.2015
  23. Capogrosso RF, Cozzoli A, Mantuano P, Camerino GM, Massari AM, Sblendorio VT, De Bellis M, Tamma R, Giustino A, Nico B, Montagnani M, De Luca A. Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone. Pharmacol Res. 2016 Apr; 106: 101-13. doi: 10.1016/j.phrs.2016.02.016
  24. Cozzoli A, Liantonio A, Conte E, Cannone M, Massari AM, Giustino A, Scaramuzzi A, Pierno S, Mantuano P, Capogrosso RF, Camerino GM, De Luca A. Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase. Am J Physiol Cell Physiol. 2014 Oct 1; 307(7): C634-47. doi: 10.1152/ajpcell.00372.2013
  25. Porcelli L, Quatrale AE, Mantuano P, Leo MG, Silvestris N, Rolland JF, Carioggia E, Lioce M, Paradiso A, Azzariti A. Optimize radiochemotherapy in pancreatic cancer: PARP inhibitors a new therapeutic opportunity. Mol Oncol. 2013 Jun; 7(3): 308-22. doi: 10.1016/j.molonc.2012.10.002
  26. Porcelli L, Quatrale AE, Mantuano P, Silvestris N, Rolland JF, Biancolillo L, Paradiso A, Azzariti A. Synergistic Antiproliferative and Antiangiogenic Effects of EGFR and mTOR Inhibitors. Curr Pharm Des. 2013; 19(5): 918-26. Review. doi: 10.2174/1381612811306050918
  27. Porcelli L, Quatrale AE, Mantuano P, Silvestris N, Brunetti AE, Calvert H, Paradiso A, Azzariti A. Synthetic lethality to overcome cancer drug resistance. Curr Med Chem. 2012; 19(23): 3858-73. Review. doi: 10.2174/092986712802002563

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pubblicato il 21/07/2017 — ultima modifica 26/01/2024