L'uso della cannabis aumenta il rischio di psicosi

Biological Psychiatry, April 1, 2016; 79:549–556

ABSTRACT
Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality
from observational designs can be problematic. We review the evidence from longitudinal studies that have
examined this relationship and discuss the epidemiologic evidence for and against interpreting the findings as
causal. We also review the evidence identifying groups at particularly high risk of developing psychosis from using
cannabis. Overall, evidence from epidemiologic studies provides strong enough evidence to warrant a public health
message that cannabis use can increase the risk of psychotic disorders. However, further studies are required to
determine the magnitude of this effect, to determine the effect of different strains of cannabis on risk, and to identify
high-risk groups particularly susceptible to the effects of cannabis on psychosis. We also discuss complementary
epidemiologic methods that can help address these questions.