Barone Michele

Attività Didattica

1. Docente incaricato di “Dietologia e Dietoterapia" per un totale di 40 ore (20 per anno, anni 1993/94 e 1994/95) presso la “Scuola S. Caterina da Siena”, Ospedale Di Venere, Bari. 2. Docente incaricato 1993/1994 di “Chimica e Biochimica" per un totale di 40 ore presso la Scuola “Francesca Fallacara”, Triggiano, Bari. 3. Docente incaricato 1994/1995 di “Malattie del’Apparato digerente" per un totale di 15 ore presso la Scuola “Francesca Fallacara”, Triggiano, Bari. 4. Docente supplente per l’anno 2003-2004 di “Gastroenterologia” per un totale di 5 ore nel Corso di Laurea di Fisioterapia, Università degli Studi di Bari. 5. Docente incaricato per l’anno 2004/2005 di “Gastroenterologia” per un totale di 12 ore nel Corso di Laurea di Fisioterapia, Università degli Studi di Bari. 6. Professore Incaricato di Gastroenterologia per il CdL in Fisioterapia dal 2005-2006. 7. Professore Incaricato di Gastroenterologia per il CdL in Infermieristivca dal 2007-2008. 8. Professore Incaricato di Gastroenterologia per il Corso di Laurea Magistrale dal 2008-2009. 9. Professore Incaricato di Gastroenterologia per il Corso di Laurea in Dietistica dal 2009-2010. 10. Professore Incaricato di Gastroenterologia per il Corso di Laurea in Dietistica dal 2010-2011. 11.Componente del Collegio dei Docenti del Dottorato di Ricerca in “Biotecnologie applicate ai trapianti di organi e tessuti”, dell’Università di Bari. 12. Componente effettivo della commissione esaminatrice del corso integrato di “Specialità medico Chirurgiche 3” corso B, IV anno, N.O.D., della Facoltà di Medicina e Chirurgia dell’Università di Bari, per la disciplina: Gastroenterologia. 13. Professore Incaricato di Gastroenterologia per il Corso di Laurea Magistrale in Medicina e Chirurgia presso l’Università di Foggia dall’anno accademico 2013-14 e 2014-15. 14. Professore Incaricato di Gastroenterologia per il Corso di Laurea in Dietistica dal 2015-2016. 15. Professore Incaricato di Gastroenterologia per il Corso di Laurea Magistrale in Medicina e Chirurgia in lingua inglese (Bari English Medical Course -BEMC-) presso l’Università di Bari, dall’anno accademico 2015-16 al 2020-2021. 16. Professore Associato di Gastroenterologia per il Corso di Laurea Magistrale in Medicina e Chirurgia in lingua inglese (Bari English Medical Course -BEMC-) presso l’Università di Bari, a partire dall’anno accademico 2021-2022. 17. Professore Incaricato di Gastroenterologia per l’insegnamento di “Gastroenterologia” e “Nutrizione nelle malattie dell’apparato digerente” al Corso di Laurea in “Scienze della Nutrizione per la Salute Umana” presso l’Università di Bari, dall’anno accademico 2019-2020 al 2020-2021. 18. Professore Associato di Gastroenterologia per l’insegnamento di “Gastroenterologia” e “Nutrizione nelle malattie dell’apparato digerente” al Corso di Laurea in “Scienze della Nutrizione per la Salute Umana” presso l’Università di Bari, dall’anno accademico 2021-2022 a tutt’oggi.

Pubblicazioni

1. Francavilla A, L Polimeno, D Conte, M Barone, G Fanizza, A ChiuMarulo, G Rizzo, M Rubino. Nuclear and cytosolic estrogen receptors in human colon carcinoma and in surrounding non cancerous colonic tissue. Gastroenterology 1987;93:1301-1306. 2. Francavilla A, A Di Leo, PK Eagon, L Polimeno, F Guglielmi, G Fanizza, M Barone, TE Starzl. Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver. Gastroenterology 1987;93:681-686. 3. Francavilla A, P Ove, L Polimeno, M Coetzee, L Makowka, M Barone, DH Van Thiel, TE Starzl. Regulation of liver size and regeneration: importance in liver transplantation. Transplant Proc 1988;20:494-97. 4. Francavilla A, P Ove, L Polimeno, M Coetzee, L Makowka, M Barone, DH Van Thiel, TE Strazl. Isolation and partial purification of hepatic stimulatory substance. Transplant Proc 1988;20: 719-21. 5. Francavilla A, L Makowka, L Polimeno, M Barone, J Demetris, FW Guglielmi, G Ambrosino, DH Van Thiel, TE Starzl. A novel model of acute hepatic failure in dogs with implications for transplantation research. Transplant Proc 1988;20:713-15. 6. Francavilla A, L Polimeno, A Di Leo, M Barone, P Ove, M Coetzee, P Eagon, L Makowka, G Ambrosino, V Mazzaferro, TE Starzl. The effect of estrogens and tamoxifen on hepatocyte proliferation in vivo and in vitro. Hepatology 1989;9:614-20. 7. Francavilla A, L Makowka, L Polimeno, M Barone, J Demetris, J Prelich, DH Van Thiel, TE Starzl. A dog model for acetaminophen-induced fulminant hepatic failure. Gastroenterology 1989;96:470-8. 8. Francavilla A, L Polimeno, A Di Leo, L Makowka, M Barone, TE Starzl. Effect of cimetidine, ranitidine, famotidine and omeprazole on hepatocyte proliferation in vitro. J Hepatology1989;8:32-41. 9. Puca FM, F Antonaci, C Panella, FW Guglielmi, M Barone, A Francavilla, R Cerutti. Psychomotor disfunctions in alcoholic and post-necrotic cirrhotic patients withouth overt encefalopathy. Acta Neurol Scand 1989;79:280-287. 10. Francavilla A, J Gavaler, L Makowka, M Barone, V Mazzaferro, G Ambrosino, S Iwatsuki, FW Guglielmi, A Di Leo, Balestrazzi, DH Van Thiel TE Starzl. Estradiol and testosterone levels in patients undergoing partial hepatectomy. A possible signal for hepatic regeneration?. Dig Dis Science 1989;34:818-822. 11. Francavilla A, M Barone, S Todo, Q Zeng, KA Porter, TE Starzl. Augmentation of rat liver regeneration by FK 506 compared with cyclosporine. Lancet, 1989;2:1248-1249. 12. Panella C, L. Makowka, M. Barone, L. Polimeno, S. Rizzi, J. Demetris, S. Bell, F. W. Guglielmi, J. G. Prelich, D. H. Van Thiel, T. E. Starzl, and A. Francavilla. Effect of ranitidine on acetaminophen-induced hepatotoxicity in dogs. Dig Dis Sci 1990;35: 385-391. 13. Francavilla A, M. Barone, T.E. Starzl, A. Zeevi, C. Scotti, G. Carrieri, V. Mazzaferro, J. Prelich, S. Todo, G. Eiras, J. Fung, and K.A. Porter. FK 506 as a growth control factor. Transplant Proc 1990;23:90-92. 14. Francavilla A, TE Starzl, Barone M, QH Zeng, KA Porter, A Zeevi, PM Markus, MRM Van Der Burck, S Todo. Studies on mechanism of augmentation of liver regeneration by cyclosporine and FK506. Hepatology 1991;14:140-143. 15. Francavilla A, TE Starzl, Ken Porter, C Scotti Foglieni, G Michalopoulos, G Carrieri, J Trejo, A Azzarone, M Barone, Qi Hua Zeng. Screening for candidate hepatic growth factors by selective portal infusion after canine Eck fistula. Hepatology 1991;14:665-670. 16. Francavilla, A, Barone, M, Polimeno, L, Van Thiel, DH, Starzl, TE. Final purification of HSS (hepatic stimulatory substance) and Therapeutic Prospectives in Acute Hepatic Failure. Acta Hepatologica Japonica 1991;32:443-464 17. Francavilla A, M Barone, A Azzarone, C Panella, A Giangaspero. Cell regeneration in the pathobiology of liver carcinomas. Ital J Gastroenterol 1991;23:589-593. 18. Polimeno L, A Azzarone, P Dell'aquila, C Amoruso, M Barone, A Angelini, DH Van Thiel, A Francavilla. Relationship between plasma and hepatic cytosolic levels of ornithine decarboxylase (ODC) and thymidine kinase (TK) in 70% hepatectomized rats. Dig Dis Sci 1991;36:289-292. 19. Francavilla A, M Barone, DH Van Thiel, V Mazzaferro, JG Prelich, TE Starzl. Further steps of hepatic stimulatory substance purification. Dig Dis Sci 1991;36:674-680. 20. Barone M, A Azzarone, A Angelini, M Zamparella, P Dell'aquila, A Francavilla. Effect of epomediol on taurocholate uptake in hepatocytes isolated from normal rats or rats with ethinylestradiol-induced cholestasis. Pharmacol Toxicol 1993;72:296-299. 21. Francavilla A, L Polimeno, M Barone, A Azzarone, TE Starzl. Hepatic regeneration and growth factors. J Surg Oncol 1993;3:1-7. 22. Barone M, C Panella, A Angelini, D Romanelli, A Francavilla. Studies in vitro on the influence of ursodeoxycholate sodium salt (UDC) on hepatocyte proliferation. J Surg Oncol 1993;3:8-13. 23. Panella C, E Ierardi, M De Marco, M Barone, FW Guglielmi, L Polimeno, A Francavilla. Does tauroursodeoxycholic acid (TUDCA) treatment increase hepatocyte proliferation in patients affected by chronic liver disease ? Ital J Gastroenterol 1995;27: 256-8. 24. Barone M, A Francavilla L Polimeno, E Ierardi, D Romanelli, P Berloco, A Di Leo, C Panella. Modulation of rat hepatocyte proliferation by salts: in vitro and in vivo studies. Hepatology 1996;23:1159-1163. 25. Capuano F, M Barone, N D’eri, E Russo, D Varone, A Francavilla, S Papa. Ursodeoxycholate promotes protein phosphorylation in the cytosol of rat hepatocytes. Biochem Mol Biol Int 1997;41:329-337. 26. Barone M, Berloco P, Ladisa R, Ierardi E, Caruso Ml, Valentini AM, Notarnicola M, Di Leo A, Francavilla A. Demonstration of a direct stimulatory effect of bile salts on rat colonic epithelial cell proliferation. Scand J Gastroenterol 2002;37:88-94. 27. Cavallini A, C Messa, M Pricci, ML Caruso, M Barone, A Di Leo. Distribution of estrogen receptor subtypes, expression of their variant forms, and clinicopathological characteristics of human colorectal cancer. Dig Dis Sci 2002;47:2720-8. 28. Barone M, Ettorre GC, Ladisa R, Schiavariello M, Santoro C, Francioso G, Vinciguerra V, Francavilla A. Transcatheter arterial chemoembolization (TACE) in treatment of hepatocellular carcinoma. Hepatogastroenterology 2003;50:183-7. 29. Ierardi E, N Muscatiello, M Nacchiero, M Gentile, M Margiotta, S Marangi, V De Francesco, R Francavilla, M Barone, D Faleo, C Panella, A Francavilla, R Cuomo. Second harmonic imaging improves trans-abdominal ultrasound detection of biliary sludge in “idiopathic” pancreatitis. Aliment Pharmacol Ther 2003;17:473-477. 30. Barone M, E Maiorano, R Ladisa, R Cuomo, A Pece, P Berloco, ML Caruso, AM Valentini, A Iolascon, A. Francavilla, A Di Leo, E Ierardi. Influence of ursodeoxycholate-enriched diet on liver tumor growth in HBV transgenic mice. Hepatology 2003;37:880-886. 31. Ierardi E, A Di Leo, M Barone, S Marangi, O Burattini, A Panarese, M Margiotta, R Francavilla, C Panella, A Francavilla, R Cuomo. Tumor necrosis factor alpha and apoptosis in Helicobacter pylori related progressive gastric damage: a possible mechanism of immune system involvement in epithelial turnover regulation. Immunopharmacol Immunotoxicol 2003;25:203-11. 32. Ierardi E, M Rendina, R Francavilla, M Barone, A Castellaneta, C Panella, A Francavilla, R Cuomo. Mycophenolate mofetil in the treatment of autoimmune HCV-associated haematological disorders showing steroid resistance or dependence. J Viral Hepat 2003;10:390-3. 33. Barone M, Maiorano E, Ladisa R, Pece A, Berloco P, Strazzabosco M, Caruso Ml, Valentini AM, Ierardi E, Di Leo A, Francavilla A. Ursodeoxycholate further increases bile-duct cell proliferative response induced by partial bile-duct ligation in rats. Virchows Arch. 2004;444:554-60. 34. De Francesco V, Zullo A, Margiotta M, Marangi S, Burattini O, Berloco P, Russo F, Barone M, Di Leo A, Minenna MF, Stoppino V, Morini S, Panella C, Francavilla A, Ierardi E. Sequential treatment for Helicobacter pylori does not share the risk factors of triple therapy failure. Aliment Pharmacol Ther. 2004;15;19:407-14. 35. Barone M. Hepatitis D-related cirrhosis and risk of hepatocellular carcinoma development. Radiology 2004;233:299. 36. Di Marzio L, Di Leo A, Cinque B, Fanini D, Agnifili A, Berloco P, Linsalata M, Lorusso D, Barone M, De Simone C, Cifone MG. Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2005;14:856-62. 37. Dell’Aquila P, Pietrini L, Barone M, Cela EM, Della Valle N, Amoruso A, Minenna MF, Penna A, De Francesco V, Panella C, Ierardi E. Small intestinal contrast ultrasonography-based scoring system A promising approach for the diagnosis and follow-up of celiac disease. J Clin Gastroenterol 2005;39:591-5. 38. Linsalata M, Russo F, Berloco P, Valentini Am, Caruso ML, De Simone C, Barone M, Polimeno L, Di Leo A. Effects of probiotic bacteria (VSL#3) on the polyamine biosynthesis and cell proliferation of normal colonic mucosa of rats. In Vivo 2005;19:989-95. 39. Barone M, Ladisa R, Di Leo A, Spano D, Francioso D, Aglio V, Amoruso A, Francavilla A, Iolascon A. Estrogen-induced proliferation in cultured hepatocytes involves cyclin d1, p21CIP1 and p27KIP1. Dig Dis Sci 2006;51:580-6. 40. Barone M, Spano D, D’apolito M, Centra M, Lasalandra C, Capasso M, Volinia S, Arcelli D, Di Leo A, Francavilla A, Tiribelli C, Iolascon A. Gene expression analysis in HBV transgenic mouse liver: a new insight into hepatocarcinogenesis. Mol Med 2006;12:115-23. 41. Castellaneta A, Di Leo A, Francavilla R, Margiotta M, Barone M, Amoruso A, Troiani L. Thomson Aw, Francavilla A. Functional modification of CD11c+ liver dendritic cells during liver regeneration after partial hepatectomy in mice. Hepatology 2006;43:807-16. 42. Avolio AW, Barone M. Use of "0" blood group liver donors for nonidentical recipients: does this represent a double penalty for "o" blood group candidates? Transplant Proc 2006;38:1063-5. 43. Barone M, Di Lernia, Carbonara M, Ladisa R, Donno A, Amoruso A, Di Leo A, Francavilla A. Sliding gastric hiatal hernia diagnosis by transabdominal ultrasonography: an easy, reliable and non-invasive procedure. Scand J Gastroenterol 2006;41:851-5. 44. Avolio AW, Agnes S, Gasbarrini A, Barbarino R, Nure E, Siciliano M, Barone M, Castagneto M. Allocation of nonstandard livers to transplant candidates with high MELD scores: Should this practice be continued? Transplant Proc 2006;38:3567-71. 45. Barone M, Avolio AW, Di Leo A, Burra P, Francavilla A. ABO blood group related waiting list disparities in liver transplant candidates: effect of the MELD adoption. Transplantation 2008;85:844-849. 46. Barone M, Tanzi S, Lofano K, Scavo MP, Guido R, Demarinis L, Principi MB, Bucci A, Di Leo A. Estrogens, phytoestrogens and colorectal neoproliferative lesions. Genes & Nutr 2008;3:7-13. 47. Di Leo A, Barone M, Maiorano E, Tanzi S, Piscitelli D, Marangi S, Lofano K, Ierardi E, Principi M, Francavilla A. ER-beta expression in large bowel adenomas: Implications in colon carcinogenesis. Dig Liver Dis 2008;40:260-6. 48. Barone M, Maiorano E, Scavo MP, Panella E, Castellaneta A, Napoli A, Francioso D, Di Leo A. and Francavilla A. Effect of gonadectomy on HCC development in HBV transgenic mice. Dig Liver Dis 2009;41:150-155. 49. Barone M, Margiotta M, Scavo MP, Gentile A, Francioso D, Papagni S, Castellaneta A, Mallamaci R, Di Leo A, Francavilla A. Possible involvement of androgen receptor alterations in hepatocarcinogenesis. Dig Liver Dis 2009;41:665-70. 50. Barone M, Tanzi S, Lofano K, Scavo MP, Pricci M, Demarinis L, Papagni S, Maiorano E, Ingravallo G, Guido R, Comelli MC, Francavilla A, Di Leo A. Dietary-induced erß up-regulation counteracts intestinal neoplasia development in intact male ApcMIN/+ mice. Carcinogenesis 2010;31:269-74. 51. Nardone G, Compare D, Liguori E, Di Mauro V, Rocco A, Barone M, Napoli A, Lapi D, Iovene MR, Colantuoni A. Protective effects of lactobacillus paracasei F19 in a rat model of oxidative and metabolic hepatic injury. Am J Physiol Gastrointest Liver Physiol. 2010; 299:G669-676. 52. Barone M, Scavo MP, Papagni S, Piscitelli D, Guido R, Di Lena M, Comelli MC, Di Leo A. ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis. Scand J Gastroenterol. 2010; 45:1320-1308. 53. Barone M, Iannone A, Corvace V, Tanzi S, Montenegro L, Licinio R, Di Leo A. Anti-Viral Therapy in Chronic HBV Infection: A Single Centre Experience. Hepatogastroenterology. 2011 Sep-Oct;58(110-111):1713-7. 54. Avolio AW, Agnes S, Siciliano M, Grieco A, Nicolotti N, Annicchiarico E, Boscarino, G, Barone M. Donor Risk Index and MELD score interactions in graft survival prediction after liver transplantation. An analysis of the OPTN-UNOS database. Open Transplantation Journal, Volume 5, Issue SPEC. ISSUE, 2011, Pages 50-55. 55. Avolio AW, Cillo U, Salizzoni M, De Carlis L, Colledan M, Gerunda GE, Mazzaferro V, Tisone G, Romagnoli R, Caccamo L, Rossi M, Vitale A, Cucchetti A, Lupo L, Gruttadauria S, Nicolotti N, Burra P, Gasbarrini A, Agnes S; Donor-to-Recipient Italian Liver Transplant (D2R-ILTx) Study Group. Balancing donor and recipient risk factors in liver transplantation: the value of D-MELD with particular reference to HCV recipients. Am J Transplant. 2011 Dec;11(12):2724-36. Collaborators (71) Barone M 56. Barone M, Lofano K, De Tullio N, Licino R, Albano F, Di Leo A. Dietary, Endocrine, and Metabolic Factors in the Development of Colorectal Cancer. J Gastrointest Cancer. 2012 Mar;43(1):13-9. 57. Avolio AW, Siciliano M, Barone M, Lai Q, Caracciolo GL, Barbarino R, Nicolotti N, Lirosi MC, Gasbarrini A, Agnes S. Model for end-stage liver disease dynamic stratification of survival benefit. Transplant Proc. 2012 Sep;44(7):1851-6. 58. Principi M, De Tullio N, Scavo MP, Piscitelli D, Marzullo A, Russo S, Albano F, Lofano K, Papagni S, Barone M, Ierardi E, Di Leo A. Estrogen receptors expression in long-lasting ulcerative pancolitis with and without dysplasia: A preliminary report. Scand J Gastroenterol 2012 Oct;47(10):1253-4. 59. Ierardi E, Giorgio F, Piscitelli D, Principi M, Cantatore S, Fiore MG, Rossi R, Barone M, Di Leo A, Panella C. Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis. World J Gastrointest Pathophysiol. 2013 Aug 15;4(3):53-8. 60. Barone M, Licinio R, Amoruso A, Viggiani MT, Larocca AM, Di Leo A. Lesson from an intriguing case of cryoglobulinemia. World J Gastroenterol. 2013 Jan 14;19(2):304-6. 61. Barone M, Altomare DF, Rotelli MT, Scavo MP, Piscitelli D, De Tullio N, Bocale D, Di Leo A. Disseminated tumour cells in bone marrow in experimental colon cancer: metastatic or resident? Colorectal Dis 2013;15(6):667-73. doi: 10.1111/codi.12169. 62. Principi M, Di Leo A, Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D, Pisani A, Ierardi E, Comelli MC, Barone M. Phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study. World J Gastroenterol. 2013 Jul 21;19(27):4325-33. 63. Facciorusso A, Antonino M, Del Prete V, Neve V, Scavo MP, Barone M. Are hematopoietic stem cells involved in hepatocarcinogenesis? Hepatobiliary Surg Nutr 2014;3:199-206. doi: 10.3978/j.issn.2304-3881.2014.06.02 64. Facciorusso A, Barone M. Glucose intolerance and hepatocellular carcinoma: recent findings for old diseases. Hepatobiliary Surg Nutr. 2014;3:91-2. doi: 10.3978/j.issn.2304-3881.2014.02.15. 65. Andriulli A, Nardi A, Di Marco V, Ippolito AM, Gavrila C, Aghemo A, Di Paolo D, Squadrito G, Grassi E, Calvaruso V, Valvano MR, Brancaccio G, Craxi A, Angelico M; Collaborators (Barone M). An a priori prediction model of response to peginterferon plus ribavirin dual therapy in naïve patients with genotype 1 chronic hepatitis C. Dig Liver Dis. 2014 Sep;46(9):818-25. doi: 10.1016/j.dld.2014.05.015 66. Andriulli A, Di Marco V, Margaglione M, Ippolito AM, Fattovich G, Smedile A, Valvano MR, Calvaruso V, Gioffreda D, Milella M, Morisco F, Felder M, Brancaccio G, Fasano M, Gatti P, Tundo P, Barone M, Cozzolongo R, Angelico M, D'Andrea G, Andriulli N, Abate ML, Mazzella G, Gaeta GB, Craxi A, Santantonio T. Identification of naïve HCV-1 patients with chronic hepatitis who may benefit from dual therapy with peg-interferon and ribavirin. J Hepatol. 2014 Jan;60(1):16-21. doi: 10.1016/j.jhep.2013.07.040. 67. Palmieri O, Ippolito AM, Margaglione M, Valvano MR, Gioffreda D, Fasano M, D'Andrea G, Corritore G, Milella M, Andriulli N, Morisco F, Giannitrapani L, Latiano A, Fontana R, Gatti P, Tundo P, Barone M, Cozzolongo R, Santantonio T, Andriulli A. A. Variation in genes encoding for interferon λ-3 and λ-4 in the prediction of HCV-1 treatment-induced viral clearance. Liver International 2014; 34(9):1369-77. doi:10.1111/liv.12411 68. Francavilla A, Pesetti B, Barone M, Morgano A, Bovenga F, Napoli A, Resta L, Russo F, Linsalata M, Minoia M, Bianco G, Tafaro A, Polimeno L. Transient GFER knockdown in vivo impairs liver regeneration after partial hepatectomy. Int J Biochem Cell Biol. 2014; 53C:343-351. doi: 10.1016/j.biocel.2014.05.029 69. Facciorusso A, Del Prete V, Antonino M, Neve V, Crucinio N, Di Leo A, Carr BI, Barone M. Serum ferritin as a new prognostic factor in hepatocellular carcinoma patients treated with radiofrequency ablation. J Gastroenterol Hepatol. 2014; 29:1905-10. doi: 10.1111/jgh.12618 70. Barone M, Viggiani MT, Amoruso A, Licinio R, Iannone A, Montenegro L, Scavo MP, Addante I, Di Leo A. Influence of age and type of underlying disease on complications related to home enteral nutrition: a single Italian center experience. JPEN J Parenter Enteral Nutr 2014 Nov;38(8):991-5. doi: 10.1177/0148607113498422 71. Barone M, Notarnicola M, Caruso MG, Scavo MP, Viggiani MT, Tutino V, Polimeno L, Pesetti B, Di Leo A, Francavilla A. Olive oil and omega-3 polyunsaturated fatty acids suppress intestinal polyp growth by modulating the apoptotic process in ApcMin/+ mice. Carcinogenesis 2014;35:1613-9. doi: 10.1093/carcin/bgu068 72. Principi M, Barone M, Pricci M, De Tullio N, Losurdo G, Ierardi E, Di Leo A. Ulcerative colitis: from inflammation to cancer. Do estrogen receptors have a role? World J Gastroenterol 2014;20:11496-504. 73. Facciorusso A, Amoruso A, Neve V, Antonino M, Prete VD, Barone M. Role of vaptans in the management of hydroelectrolytic imbalance in liver cirrhosis. World J Hepatol. 2014; 6:793-9. doi: 10.4254/wjh.v6.i11.793. 74. Barone M, Iannone A, Di Leo A. HBsAg clearance by Peg-Interferon addition to a long-term nucleos(t)ide analogues therapy. World J Gastroenterol 2014; 20: 8722-5. doi: 10.3748/wjg.v20.i26.8722 75. Barone M, Scavo MP, Maiorano E, Di Leo A, Francavilla A. Bone marrow-derived stem cells and hepatocarcinogenesis in hepatitis B virus transgenic mice. Dig Liver Dis. 2014; 46:243-50. doi: 10.1016/j.dld.2013.10.008. 76. Facciorusso A, Del Prete V, Antonino M, Crucinio N, Neve V, Di Leo A, Carr BI, Barone M. Post-recurrence survival in hepatocellular carcinoma after percutaneous radiofrequency ablation. Digestive and Liver Disease 2015; 46:1014-9. doi: 10.1016/j.dld.2014.07.012. 77. Barone M, Viggiani MT, Amoruso A, Schiraldi S, Zito A, Devito F, Cortese F, Gesualdo M, Brunetti N, Di Leo A, Scicchitano P, Ciccone MM. Endothelial dysfunction correlates with liver fibrosis in chronic HCV infection. Gastroenterol Res Pract. 2015; 2015:682174. doi: 10.1155/2015/682174 78. Barone M, Notarnicola A, Lopalco G, Viggiani MT, Sebastiani F, Covelli M, Iannone F, Avolio AW, Di Leo A, Cantarini L, Lapadula G. Safety of long-term biologic therapy in rheumatologic patients with a previously resolved hepatitis B viral infection. Hepatology. 2015;62:40-46. doi: 10.1002/hep.27716. 79. Facciorusso A, Del Prete V, Antonino M, Neve V, Amoruso A, Crucinio N, Di Leo A, Barone M. Conditional survival analysis of hepatocellular carcinoma patients treated with radiofrequency ablation. Hepatol Res 2015;45:E62-72. doi: 10.1111/hepr.12458. 80. Barone M, Scavo MP, Licinio R, Piombino M, De Tullio N, Mallamaci R, Di Leo A. Role of Bone Marrow-Derived Stem Cells in Polyps Development in Mice with Apc(Min/+) Mutation. Stem Cells Int. 2015;2015:354193. doi: 10.1155/2015/354193. 81. Facciorusso A, Di Maso M, Antonino M, Del Prete V, Panella C, Barone M, Muscatiello N. Polidocanol injection decreases the bleeding rate after colon polypectomy: a propensity score analysis. Gastrointest Endosc 2015;82:350-358. doi: 10.1016/j.gie.2015.01.003 82. Facciorusso A, Del Prete V, Crucinio N, Muscatiello N, Carr BI, Di Leo A, Barone M. Angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients. J Gastroenterol Hepatol 2015; 30:1643-50. doi: 10.1111/jgh.12988. 83. Facciorusso A, Licinio R, Carr BI, Di Leo A, Barone M. MEK 1/2 inhibitors in the treatment of hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol 2015; 9:993-1003. doi: 10.1586/17474124.2015.1040763. 84. Facciorusso A, Licinio R, Muscatiello N, Di Leo A, Barone M. Transarterial chemoembolization: Evidences from the literature and applications in hepatocellular carcinoma patients. World J Hepatol 2015;7:2009-19. doi: 10.4254/wjh.v7.i16.2009 85. Facciorusso A, Muscatiello N, Barone M. Letter: prognostic scoring systems for hepatocellular carcinoma patients--the jury is still out. Aliment Pharmacol Ther 2015;41:596-7. doi: 10.1111/apt.13078 86. Facciorusso A, Muscatiello N, Di Leo A, Barone M. Combination therapy with sorafenib and radiofrequency ablation for hepatocellular carcinoma: a glimmer of light after the storm trial? Am J Gastroenterol 2015;110:770-1. doi: 10.1038/ajg.2015.80. 87. Facciorusso A, Maso MD, Barone M, Muscatiello N. Echoendoscopic ethanol ablation of tumor combined to celiac plexsus neurolysis improved pain control in a patient with pancreatic adenocarcinoma. Endosc Ultrasound 2015;4:342-44. 88. Barone M. Neurophysiologic and psychometric tests in the diagnosis of low-grade encephalopathy. Gastroenterology. 2015 Mar;148(3):663. doi: 10.1053/j.gastro.2014.10.062 89. Barone M, Iannone A, Brunetti ND, Sebastiani F, Cecere O, Berardi E, Antonica G, Di Leo A. Liver stiffness and portal blood flow modifications induced by a liquid meal consumption: pathogenetic mechanisms and clinical relevance. Scand J Gastroenterol 2015;50:560-6. doi: 10.3109/00365521.2014.1003396 90. Facciorusso A, Antonino M, Di Maso M, Barone M, Muscatiello N. Non-polypoid colorectal neoplasms: Classification, therapy and follow-up. World J Gastroenterol 2015; 21:5149-5157. doi: 10.3748/wjg.v21.i17.5149. 91. Giorgio F, Principi M, Losurdo G, Piscitelli D, Iannone A, Barone M, Amoruso A, Ierardi E, Di Leo A. Seronegative Celiac Disease and Immunoglobulin Deficiency: Where to Look in the Submerged Iceberg? Nutrients 2015;7:7486-504. doi: 10.3390/nu7095350. 92. Facciorusso A, Antonino M, Del Prete V, Amoruso A, Neve V, Barone M. Medical Systemic Therapies for Hepatocellular Carcinoma: Clinical Perspectives and Safety Profile. Curr Drug Saf 2015; 10: 202-207. 93. Scavo MP, Gentile E, Wolfram J, Gu J, Barone M, Evangelopoulos M, Martinez JO, Liu X, Celia C, Tasciotti E, Vilar E, Shen H. Multistage vector delivery of sulindac and silymarin for prevention of colon cancer. Colloids Surf B Biointerfaces 2015;136:694-703. doi: 10.1016/j.colsurfb.2015.10.005 94. Barone M, Della Valle N, Rosania R, Facciorusso A, Trotta A, Cantatore FP, Falco S, Pignatiello S, Viggiani MT, Amoruso A, De Filippis R, Di Leo A, Francavilla R. A comparison of the nutritional status between adult celiac patients on a long-term, strictly gluten-free diet and healthy subjects. Eur J Clin Nutr 2016;70:23-7. doi: 10.1038/ejcn.2015.114. 95. Facciorusso A, Mariani L, Sposito C, Spreafico C, Bongini M, Morosi C, Cascella T, Marchianò A, Camerini T, Bhoori S, Brunero F, Barone M, Mazzaferro V. Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma. J Gastroenterol Hepatol 2016;31:645-53. doi: 10.1111/jgh.13147 96. Losurdo G, Iannone A, Principi M, Barone M, Ranaldo N, Ierardi E, Di Leo A. Acute pancreatitis in elderly patients: A retrospective evaluation at hospital admission. Eur J Intern Med 2016;30:88-93. doi: 10.1016/j.ejim.2016.01.011. Epub 2016 Jan 22. 97. Principi M, Cassano N, Contaldo A, Iannone A, Losurdo G, Barone M, Mastrolonardo M, Vena GA, Ierardi E, Di Leo A. Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association. World J Gastroenterol. 2016 May 28;22(20):4802-11. doi: 10.3748/wjg.v22.i20.4802 98. Iannone A, Losurdo G, Pricci M, Girardi B, Massaro A, Principi M, Barone M, Ierardi E, Di Leo A. Stool Investigations for Colorectal Cancer Screening: From Occult Blood Test to DNA Analysis. J Gastrointest Cancer 2016;47:143-51. doi: 10.1007/s12029-016-9810-z. 99. Notarnicola M, Barone M, Francavilla A, Tutino V, Bianco G, Tafaro A, Minoia M, Polimeno L, Napoli A, Scavo MP, Caruso MG. Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model. Oncol Rep 2016;36:893-9. doi: 10.3892/or.2016.4856. 100. Facciorusso A, Del Prete V, Muscatiello N, Crucinio N, Barone M. Prognostic role of 25-hydroxyvitamin d in patients with liver metastases from colorectal cancer treated with radiofrequency ablation. J Gastroenterol Hepatol 2016;31:1483-8. doi: 10.1111/jgh.13326. 101. Iannone A, Principi M, Barone M, Losurdo G, Ierardi E, Di Leo A. Gastrointestinal bleeding from vascular malformations: Is octreotide effective to rescue difficult-to-treat patients? Clin Res Hepatol Gastroenterol 2016;40:373-377. 102. Losurdo G, Giorgio F, Piscitelli D, Montenegro L, Covelli C, Fiore MG, Giangaspero A, Iannone A, Principi M, Amoruso A, Barone M, Di Leo A, Ierardi E. May the assessment of baseline mucosal molecular pattern predict the development of gluten related disorders among microscopic enteritis? World J Gastroenterol. 2016 Sep 21;22(35):8017-25. doi: 10.3748/wjg.v22.i35.8017. 103. Losurdo G, Giorgio F, Iannone A, Principi M, Barone M, Di Leo A, Ierardi E. Role of concomitant therapy for Helicobacter pylori eradication: A technical note. World J Gastroenterol. 2016 Oct 14;22(38):8638-8640 104. Licinio R, Losurdo G, Carparelli S, Iannone A, Giorgio F, Barone M, Principi M, Ierardi E, Di Leo A. Helicobacter pylori, liver cirrhosis, and portal hypertension: an updated appraisal. Immunopharmacol Immunotoxicol. 2016 Oct 27:1-6. 105. Giorgio F, Ierardi E, Sorrentino C, Principi M, Barone M, Losurdo G, Iannone A, Giangaspero A, Monno R, Di Leo A. Helicobacter pylori DNA isolation in the stool: an essential pre-requisite for bacterial noninvasive molecular analysis. Scand J Gastroenterol. 2016 Dec;51(12):1429-1432. 106. Lopalco G, Rigante D, Venerito V, Fabiani C, Franceschini R, Barone M, Lapadula G, Galeazzi M, Frediani B, Iannone F, Cantarini L. Update on the Medical Management of Gastrointestinal Behçet's Disease. Mediators Inflamm 2017;2017:1460491. 107. Giannitti C, Lopalco G, Vitale A, Rigante D, Anelli MG, Fabbroni M, Manganelli S, Galeazzi M, Frediani B, Barone M, Lapadula G, Iannone F, Cantarini L. Long-term safety of anti-TNF agents on the liver of patients with spondyloarthritis and potential occult hepatitis B viral infection: an observational multicentre study. Clin Exp Rheumatol. 2017 Jan-Feb;35(1):93-97 108. Ierardi E, Losurdo G, Iannone A, Piscitelli D, Amoruso A, Barone M, Principi M, Pisani A, Di Leo A. Lymphocytic duodenitis or microscopic enteritis and gluten‑related conditions: what needs to be explored? Ann Gastroenterol. 2017;30:380-392. doi: 10.20524/aog.2017.0165 109. Ranaldo N, Losurdo G, Iannone A, Principi M, Barone M, De Carne M, Ierardi E, Di Leo A. Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease. Cell Death Dis. 2017; 8:e3040. doi: 10.1038/cddis.2017.436 110. Shahini E, Iannone A, Giangaspero A, Castellaneta NM, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A. Epstein-Barr Virus-Related Hyperacute Hepatitis: May Intravenous Steroids be an Effective Approach? Anti-infective Agents 2017;15. DOI: 10.2174/2211352514666160923161105 111. Barone M, Shahini, E, Di Leo, A. Letter: can transient elastography and body mass index predict fibrosis regression in HBV patients on long-term nucleoside therapy? Alimentary Pharmacology and Therapeutics 2017; 45:765-766. 112. Ierardi E, Giorgio F, Iannone A, Losurdo G, Principi M, Barone M, Pisani A, Di Leo A. Noninvasive molecular analysis of Helicobacter pylori: iis it time for tailored first-line therapy? World Journal of Gastroenterology 2017; 23:2453-2458. 113. Petta S, Marzioni M, Russo P, Aghemo A, Alberti A, Ascione A, Antinori A, Bruno R, Bruno S, Chirianni A, Gaeta GB, Giannini EG, Merli M, Messina V, Montilla S, Perno CF, Puoti M, Raimondo G, Rendina M, Silberstein FC, Villa E, Zignego AL, Pani L, Craxì A; ABACUS study group; AIFA team. Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with cirrhosis (ABACUS): a prospective observational study. Lancet Gastroenterol Hepatol 2017; 2:427-434. doi: 10.1016/S2468-1253(17)30048-1 114. Losurdo G, Marra A, Shahini E, Girardi B, Giorgio F, Amoruso A, Pisani A, Piscitelli D, Barone M, Principi M, Di Leo A, Ierardi E. Small intestinal bacterial overgrowth and celiac disease: A systematic review with pooled-data analysis. Neurogastroenterol Motil. 2017 Jun;29(6) :e13028.. doi: 10.1111/nmo.13028. 115. Barone M, Viggiani MT, Losurdo G, Principi M, Leandro G, Di Leo A. Systematic review with meta-analysis: post-operative complications and mortality risk in liver transplant candidates with obesity. Aliment Pharmacol Ther. 2017;46:236-245. doi: 10.1111/apt.14139 116. Barone M, Viggiani MT, Losurdo G, Principi M, Leandro G, Di Leo A. Editorial: liver transplantation in patients with non-alcoholic fatty liver disease and obesity—authors’ reply. Aliment Pharmacol Ther 2017;46:460-461. doi: 10.1111/apt.14195 117. Ippolito AM, Milella M, Messina V, Conti F, Cozzolongo R, Morisco F, Brancaccio G, Barone M, Santantonio T, Masetti C, Tundo P, Smedile A, Carretta V, Gatti P, Termite AP, Valvano MR, Bruno G, Fabrizio C, Andreone P, Zappimbulso M, Gaeta GB, Napoli N, Fontanella L, Lauletta G, Cuccorese G, Metrangolo A, Francavilla R, Ciracì E, Rizzo S, Andriulli A. HCV clearance after direct-acting antivirals in patients with cirrhosis by stages of liver impairment: The ITAL-C network study. Dig Liver Dis 2017;49:1022-1028. 118. Barone M, Viggiani MT, Avolio AW, Iannone A, Rendina M, Di Leo A. Obesity as predictor of postoperative outcomes in liver transplant candidates: Review of the literature and future perspectives. Digestive and Liver Disease 2017; 49:957–966. doi: 10.1016/j.dld.2017.07.004. 119. Viggiani MT, Lorusso O, Natalizio F, Principi M, Di Leo A, Barone M. Influence of chemotherapy on total energy expenditure in patients with gastrointestinal cancer: A pilot study. Nutrition 2017;42:7-11. doi: 10.1016/j.nut.2017.05.001 120. Iannone A, Ruospo M, Wong G, Principi M, Barone M, Strippoli GFM, Di Leo A. Chromoendoscopy for Surveillance in Ulcerative Colitis and Crohn’s Disease: A Systematic Review of Randomized Trials. Clinical Gastroenterology and Hepatology 2017;15:1684–1697. doi: 10.1016/j.cgh.2016.11.021 121. Losurdo G, Iannone A, Giorgio F, Barone M, Principi M, Ierardi E, Di Leo A. Sequential Therapy For Helicobacter pylori in Elderly Patients: Effectiveness, Safety and Predictors of Success. Letters in Drug Design & Discovery, 2017, 14, 1-6. 122. Barone M, Iannone A, Shahini E, Ippolito AM, Brancaccio G, Morisco F, Milella M, Messina V, Smedile A, Conti F, Gatti P, Santantonio T, Tundo P, Lauletta G, Napoli N, Masetti C, Termite AP, Francavilla R, Di Leo A, Pesce F, Andriulli A. A different perspective on sofosbuvir-ledipasvir treatment of patients with HCV genotype 1b cirrhosis: the ITAL-C network study. J Viral Hepat 2018;25:56-62. doi: 10.1111/jvh.12765 123. Iannone A, Giorgio F, Russo F, Riezzo G, Girardi B, Pricci M, Palmer SC, Barone M, Principi M, Strippoli GF, Di Leo A, Ierardi E. New fecal test for non-invasive Helicobacter pylori detection: A diagnostic accuracy study. World J Gastroenterol. 2018 Jul 21;24(27):3021-3029. doi: 10.3748/wjg.v24.i27.3021. 124. Ippolito AM, Iacobellis A, Milella M, Conti F, Messina V, Valvano MR, Niro GA, Morisco F, Barone M, Termite AP, Brancaccio G, Andriulli A. Hepatitis C Virus Clearance in Older Adults. J Am Geriatr Soc 66:85–91, 2018. doi: 10.1111/jgs.15140 125. Losurdo G, Principi M, Girardi B, Pricci M, Barone M, Ierardi E, Di Leo A. Histamine and histaminergic receptors in colorectal cancer: From basic science to evidence-based medicine. Anticancer Agents Med Chem 2018; 18:5-20. doi: 10.2174/1871520616666160321115349 126. Barone M, Viggiani MT, Losurdo G, Principi M, Leandro G, Di Leo A. Letter: dose-response analysis revealed closer relationship between obesity and perioperative outcomes in patients after liver transplantation. Aliment Pharmacol Ther. 2018 Jan;47(2):312-313. doi: 10.1111/apt.14446. 127. Losurdo G, Cubisino R, Barone M, Principi M, Leandro G, Ierardi E, Di Leo A. Probiotic monotherapy and Helicobacter pylori eradication: A systematic review with pooled-data analysis. World J Gastroenterol. 2018; 24:139-149. doi: 10.3748/wjg.v24.i1.139. 128. Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, Barone M. Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm. World J Gastroenterol. 2018; 24:1521–1530. doi: 10.3748/wjg.v24.i14.1521 129. Barone M, Shahini E, Iannone A, Viggiani MT, Corvace V, Principi M, Di Leo A. Critical flicker frequency test predicts overt hepatic encephalopathy and survival in patients with liver cirrhosis. Dig Liv Dis. 2018;50:496-500. 10.1016/j.dld.2018.01.133 130. Ascione A, De Luca M, Melazzini M, Montilla S, Trotta MP, Petta S, Puoti M, Sangiovanni V, Messina V, Bruno S, Izzi A, Villa E, Aghemo A, Zignego AL, Orlandini A, Fontanella L, Gasbarrini A, Marzioni M, Giannini EG, Craxì A; ABACUS Study Group. Safety and efficacy of ombitasvir/paritaprevir/ritonavir/dasabuvir plus ribavirin in patients over 65 years with HCV genotype 1 cirrhosis. Infection. 2018 May 28. doi: 10.1007/s15010-018-1157-x. 131. Principi M, Losurdo G, Iannone A, Contaldo A, Deflorio V, Ranaldo N, Pisani A, Ierardi E, Di Leo A, Barone M. Differences in dietary habits between patients with inflammatory bowel disease in clinical remission and a healthy population. Ann Gastroenterol. 2018; 31: 469–473. doi: 10.20524/aog.2018.0273. 132. Girardi B, Principi M, Pricci M, Giorgio F, Iannone A, Losurdo G, Ierardi E, Di Leo A, Barone M. Chemoprevention of inflammation-related colorectal cancer by silymarin-, acetyl-11-keto-beta-boswellic acid-, curcumin- and maltodextrin-enriched dietetic formulation in animal model. Carcinogenesis 2018; 39:1274-1282. Doi 10.1093/carcin/bgy104 133. Barone M. Is the use of the BMI alone sufficient to diagnose malnutrition in both male and female adults? Clin Nutr. 2018;37:1771. doi: 10.1016/j.clnu.2018.07.003 134. Losurdo G, Principi M, Iannone A, Giangaspero A, Piscitelli D, Ierardi E, Di Leo A, Barone M. Predictivity of Autoimmune Stigmata for Gluten Sensitivity in Subjects with Microscopic Enteritis: A Retrospective Study. Nutrients. 2018 18;10. pii: E2001. doi: 10.3390/nu10122001. 135. Shahini E, Iannone A, Romagno D, Armandi A, Carparelli S, Principi M, Viggiani MT, Ierardi E, Di Leo A, Barone M. Clinical relevance of serum non-organ-specific 1 antibodies in HCV patients receiving direct‐acting antiviral therapy. Aliment Pharmacol Ther 2018; 48:1138-1145. 136. Iannone A, Ruospo M, Wong G, Barone M, Principi M, Di Leo A, Strippoli GFM. Mesalazine for People with Diverticular Disease: A Systematic Review of Randomized Controlled Trials. Can J Gastroenterol Hepatol. 2018;2018:5437135. 137. Principi M, Iannone A, Losurdo G, Mangia M, Shahini E1, Albano F, Rizzi SF, La Fortezza RF, Lovero R, Contaldo A, Barone M, Leandro G, Ierardi E, Di Leo A. Nonalcoholic Fatty Liver Disease in Inflammatory Bowel Disease: Prevalence and Risk Factors. Inflamm Bowel Dis. 2018;24:1589-1596. 138. Barone M, Viggiani MT, Anelli MG, Fanizzi R, Lorusso O, Lopalco G, Cantarini L, Di Leo A, Lapadula G, Iannone F. Sarcopenia in Patients with Rheumatic Diseases: Prevalence and Associated Risk Factors. J Clin Med. 2018;7(12). doi: 10.3390/jcm7120504 139. Francavilla R, Piccolo M, Francavilla A, Polimeno L, Semeraro F, Cristofori F, Castellaneta S, Barone M, Indrio F, Gobbetti M, De Angelis M. Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients with Persistent IBS-type Symptoms: A Randomized, Double-Blind, Placebo-controlled, Multicenter Trial. J Clin Gastroenterol 2019; 53:117-e125. DOI: 10.1097/MCG.0000000000001023 Scopus ID: 2-s2.0-85057948260 140. Contaldo A, Losurdo G, Albano F, Iannone A, Barone M, Ierardi E, Di Leo A, Principi M. The Spectrum of Small Intestinal Lesions in Patients with Unexplained Iron Deficiency Anemia Detected by Video Capsule Endoscopy. Medicina (Kaunas) 2019;55:59. doi: 10.3390/medicina55030059 141. Ji F, Yeo YH, Wei MT, Ogawa E, Enomoto M, Lee DH, Iio E, Lubel J, Wang W, Wei B, Ide T, Preda CM, Conti F, Minami T, Bielen R, Sezaki H, Barone M, Kolly P, Chu PS, Virlogeux V, Eurich D, Henry L, Bass MB, Kanai T, Dang S, Li Z, Dufour JF, Zoulim F, Andreone P, Cheung RC, Tanaka Y, Furusyo N, Toyoda H, Tamori A, Nguyen MH. J. Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis. J Hepatol 2019; 71:473-485. DOI: 10.1016/j.jhep.2019.04.017. SCOPUS ID: 2-s2.0-85067690668. 142. Barone M, Viggiani MT, Losurdo G, Principi M, Leo AD. Systematic review: Renin-angiotensin system inhibitors in chemoprevention of hepatocellular carcinoma. World J Gastroenterol. 2019 May 28;25(20):2524-2538. doi: 10.3748/wjg.v25.i20.2524. 143. Viggiani MT, Di Leo A, Barone M. Can the antisecretory factor be considered a new therapy for the short bowel syndrome? Nutr Metab Insights. 2019 May 23;12:1178638819852061. doi: 10.1177/1178638819852061 144. Rendina M, Viggiani MT, Di Leo A, Barone M. Malnutrition, sarcopenia, and refractory ascites in end stage liver diseases: is there a way to climb back up? Dig Liver Dis. 2019 Jul 2. pii: S1590-8658(19)30639-5. doi: 10.1016/j.dld.2019.06.002. 145. Viggiani MT, Polimeno L, Di Leo A, Barone M. Phytoestrogens: Dietary Intake, Bioavailability, and Protective Mechanisms against Colorectal Neoproliferative Lesions. Nutrients. 2019;11(8). pii: E1709. doi: 10.3390/nu11081709. 146. Ierardi E, Losurdo G, Fortezza RF, Principi M, Barone M, Di Leo A. Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness. World J Gastroenterol 2019;25:5097-5104. doi: 10.3748/wjg.v25.i34.5097 147. Iannone A, Ruospo M, Palmer SC, Principi M, Barone M, Di Leo A, Strippoli GFM. Systematic review with network meta-analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease. Aliment Pharmacol Ther 2019;50:858-871. Doi: 10.1111/apt.15493. SCOPUS ID: 2-s2.0-85072019090 148. Barone M, Viggiani MT, Introna A, D'errico E, Scarafino A, Iannone A, Di Leo A, Simone IL. Nutritional prognostic factors for survival in amyotrophic lateral sclerosis patients undergone percutaneous endoscopic gastrostomy placement. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jul 26:1-7. doi: 10.1080/21678421.2019.1643374 149. Polimeno L, Barone M, Mosca A, Viggiani MT, Di Leo A, Debellis L, Troisi M, Daniele A, Santacroce L. Gut Microbiota Imbalance is Related to Sporadic Colorectal Neoplasms. A Pilot Study. Appl. Sci. 2019, 9, 5491; doi:10.3390/app9245491. 150. Daniele A, Paradiso AV, Divella R, Digennaro M, Patruno M, Tommasi S, Pilato B, Tufaro A, Barone M, Minoia C, Colangelo D, Savino E, Casamassima P, Bruno E, Oliverio A, Pasanisi P. The Role of Circulating Adiponectin and SNP276G>T at ADIPOQ Gene in BRCA-mutant Women. Cancer Genomics Proteomics 2020;17(3):301-307. doi: 10.21873/cgp.20190. 151. Losurdo G, Leandro G, Ierardi E, Perri F, Barone M, Principi M, Di Leo A. Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis. J Neurogastroenterol Motil 2020;26:16-28. doi: 10.5056/jnm19113. 152. Piazzolla M, Castellaneta N, Novelli A, Agolini E, Cocciadiferro D, Resta L, Duda L, Barone M, Ierardi E, Di Leo A. Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature. World J Hepatol 2020; 12 (2), 64-71. Doi: 10.4254/wjh.v12.i2.0000 153. Cerletti C, Colucci M, Storto M, Semeraro F, Ammollo CT, Incampo F, Costanzo S, De Bartolomeo G, Portincasa P, Barone M, Di Castelnuovo A, Semeraro N, Iacoviello L, De Gaetano G. Randomized trial of chronic supplementation with a nutraceutical mixture to subjects with Non Alcoholic Fatty Liver Disease (NAFLD). British J Nutr. 2020;123:190-197. doi: 10.1017/S0007114519002484 154. Barone M, Gemello E, Viggiani MT, Cristofori F, Renna C, Iannone A, Di Leo A, Francavilla R. Evaluation of non-celiac gluten sensitivity in patients with previous diagnosis of irritable bowel syndrome: a randomized double-blind placebo-controlled crossover trial. Nutrients 2020, 12, 705; doi:10.3390/nu12030705. 155. Polimeno L, Barone M, Mosca A, Viggiani MT, Joukar F, Mansour-Ghanaei F, Mavaddati S, Daniele A, Debellis L, Bilancia L, Santacroce L, Di Leo A. Soy Metabolism by Gut Microbiota from Patients with Precancerous Intestinal Lesions. Microorganisms 2020, 8, 469; doi:10.3390/microorganisms8040469 156. Francavilla R, Cristofori F, Vacca M, Barone M, Maria De Angelis. Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease. Expert Review of Gastroenterology & Hepatology, DOI: 10.1080/17474124.2020.1745630 157. Sangiovanni A, Alimenti E, Gattai R, Filomia R, Parente E, Valenti L, Marzi L, Pellegatta G, Borgia G, Gambato M, Terreni N, Serio I, Belli L, Oliveri F, Maimone S, Brunacci M, D'Ambrosio R, Forzenigo LV, Russo FP, Rumi M, Barone M, Fracanzani AL, Raimondo G, Giannini EG, Brunetto MR, Villa E, Biganzoli E, Colombo M, Lampertico P. Undefined/non-malignant hepatic nodules are associated with early occurrence of HCC in DAA-treated patients with HCV-related cirrhosis. J Hepatol 2020;73:593-602. doi: 10.1016/j.jhep.2020.03.030. 158. Girardi B, Pricci M, Giorgio F, Piazzolla M, Iannone A, Losurdo G, Principi M, Barone M, Ierardi E, Di Leo A. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World J Gastroenterol 2020 April 14; 26(14): 0-0. DOI: 10.3748/wjg.v26.i14.0000. 159. Barone M, Di Leo A, Sabbà C, Mazzocca A. The perplexity of targeting genetic alterations in hepatocellular carcinoma. Med Oncol. 2020;37:67. doi: 0.1007/s12032-020-01392-8. 160. Losurdo G, Iannone A, Contaldo A, Barone M, Ierardi E, Di Leo A, Principi M. Chronic viral hepatitis in a cohort of inflammatory bowel disease patients from southern Italy: A case-control study. Phatogens 2020;9:1-10. doi: 10.3390/pathogens9110870 161. Losurdo G, Iannone A, Contaldo A, Barone M, Ierardi E, Di Leo A, Principi M. Trends of liver stiffness in inflammatory bowel disease with chronic hepatitis C. Diagnostics (Basel). 2020 Dec 2;10(12):1037. doi: 10.3390/diagnostics10121037. 162. Losurdo G, La Fortezza RF, Iannone A, Contaldo A, Barone M, Ierardi E, Di Leo A, Principi M. Prevalence and associated factors of obesity in inflammatory bowel disease: A case-control study. World J Gastroenterol. 2020 Dec 21;26(47):7528-7537. doi: 10.3748/wjg.v26.i47.7528. 163. Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R. Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body. Front Immunol. 2021 Feb 26;12:578386. doi: 10.3389/fimmu.2021.578386. 164. Delvecchio M, Bizzoco F, Lapolla R, Gentile A, Carrozza C, Barone M, Simonetti S, Giordano P, Dargenio VN, Cristofori F, Francavilla R. Iodine Absorption in Celiac Children: A Longitudinal Pilot Study. Nutrients. 2021 Mar 1;13(3):808. doi: 10.3390/nu13030808. 165. Barone M, Suppressa P, Viggiani MT, Lenato GM, Scardapane A, Chiumarulo L, Ambrosini N, Leo AD, Sabbà C. Minimal portosystemic encephalopathy: A new nosological entity in patients with hereditary haemorrhagic telangiectasia. Eur J Intern Med 2021 May 18;S0953-6205(21)00149-7. doi: 10.1016/j.ejim.2021.04.026. 166. Cristofori F, D'Abramo FS, Rutigliano V, Dargenio VN, Castellaneta S, Piscitelli D, De Benedittis D, Indrio F, Raguseo LC, Barone M, Francavilla R. Esophageal eosinophilia and eosinophilic esophagitis in celiac children: A ten-year prospective observational study. Nutrients 2021 24;13(11):3755. doi: 10.3390/nu13113755. 167. Losurdo G, Brescia IV, Lillo C, Mezzapesa M, Barone M, Principi M, Ierardi E, Di Leo A, Rendina M. Liver involvement in inflammatory bowel disease: What should the clinician know? World J Hepatol. 2021 Nov 27;13(11):1534-1551. doi: 10.4254/wjh.v13.i11.1534. 168. Barone M, Venerito V, Paolillo R, Emmi G, Fornaro M, Cacciapaglia F, Cantarini L, Di Leo A, Iannone F, Lopalco G. Long-term safety of rituximab in rheumatic patients with previously resolved hepatitis B virus infection. Intern Emerg Med. 2022 Mar;17(2):475-480. doi: 10.1007/s11739-021-02836-3 169. Polimeno L, Viggiani MT, Giorgio F, Polimeno L, Fratantonio D, Di Domenico M, Boccellino M, Ballini A, Topi S, Di Leo A, Santacroce L, Barone M. Possible role of nuclear factor erythroid 2-related factor 2 in the progression of human colon precancerous lesions. Dig Liver Dis. 2022 Feb 21:S1590-8658(22)00142-6. doi: 10.1016/j.dld.2022.01.131. 170. Colaianni G, Oranger A, Dicarlo M, Lovero R, Storlino G, Pignataro P, Fontana A, Di Serio F, Ingravallo A, Caputo G, Di Leo A, Barone M, Grano M. Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients. Front Endocrinol (Lausanne). 2022 May 12;13:886243. doi: 10.3389/fendo.2022.886243. 171. Concas G, Barone M, Francavilla R, Cristofori F, Dargenio VN, Giorgio R, Dargenio C, Fanos V, Marcialis MA. Twelve Months with COVID-19: What Gastroenterologists Need to Know. Dig Dis Sci. 2022 Jul;67(7):2771-2791. doi: 10.1007/s10620-021-07158-0. 172. Barone M, Losurdo G, Iannone A, Leandro G, Di Leo A, Trerotoli P. Assessment of body composition: Intrinsic methodological limitations and statistical pitfalls. Nutrition. 2022 May 14;102:111736. doi: 10.1016/j.nut.2022.111736. 173. Rendina M, Paoletti E, Labarile N, Marra A, Iannone A, Castellaneta A, Bussalino E, Ravera M, Schena A, Castellaneta NM, Barone M, Simone S, Gesualdo L, Di Leo A. HCV-positive kidney transplant patients treated with direct-acting antivirals maintain stable medium-term graft function despite persistent reduction in tacrolimus trough levels. Ther Adv Chronic Dis. 2022 Sep 17;13:20406223221117975. 174. Barone M, Iannone A, Cristofori F, Dargenio VN, Indrio F, Verduci E, Di Leo A, Francavilla R. Risk of obesity during a gluten-free diet in pediatric and adult patients with celiac disease: a systematic review with meta-analysis. Nutr Rev. 2023 Feb 10;81(3):252-266. doi: 10.1093/nutrit/nuac052. 175. Losurdo G, Caccavo NLB, Indellicati G, Celiberto F, Ierardi E, Barone M, Di Leo A. Effect of Long-Term Proton Pump Inhibitor Use on Blood Vitamins and Minerals: A Primary Care Setting Study. J Clin Med. 2023 Apr 17;12(8):2910. doi: 10.3390/jcm12082910. 176. Barone M, Leo AD, de van der Schueren MAE. Malnutrition assessment by Global Leadership Initiative on Malnutrition criteria in patients with amyotrophic lateral sclerosis. Nutrition. 2023 May;109:111997. doi: 10.1016/j.nut.2023.111997. 177. Riggio O, Celsa C, Calvaruso V, Merli M, Caraceni P, Montagnese S, Mora V, Milana M, Saracco GM, Raimondo G, Benedetti A, Burra P, Sacco R, Persico M, Schepis F, Villa E, Colecchia A, Fagiuoli S, Pirisi M, Barone M, Azzaroli F, Soardo G, Russello M, Morisco F, Labanca S, Fracanzani AL, Pietrangelo A, Di Maria G, Nardelli S, Ridola L, Gasbarrini A, Cammà C. Hepatic encephalopathy increases the risk for mortality and hospital readmission in decompensated cirrhotic patients: a prospective multicenter study. Front Med (Lausanne). 2023 May 25;10:1184860. doi: 10.3389/fmed.2023.1184860. 178. D'Amico V, Denora N, Ivone M, Iacobazzi RM, Laquintana V, Cutrignelli A, Franco M, Barone M, Lopalco A, Lopedota AA. Investigating the prilling/vibration technique to produce gastric-directed drug delivery systems for misoprostol. Int J Pharm. 2024 Jan 5;651:123762. doi: 10.1016/j.ijpharm.2023.123762.

Ricerca

Il mio interesse scientifico durante i primi anni si è concentrato sullo studio dei fattori che modulano i processi proliferativi (ormoni, fattori di crescita, immunofilline, sali biliari, proteine modulanti il ciclo cellulare, ecc.) utilizzando vari modelli sperimentali in vivo e in vitro. I risultati conseguiti, lavorando presso l’Università di Pittsburgh come Ricercatore Associato prima, e poi presso l’Università di Bari, hanno consentito la purificazione e la caratterizzazione dell’HSS (Hepatic stimulatory Substance), poi denominata ALR (Augmenter of Liver Regeneration), e la definizione del ruolo dei sali biliari e degli ormoni steroidei sessuali nella modulazione della proliferazione, sia nel fegato che nel colon. Successivamente, ho studiato il ruolo dei sali biliari e degli ormoni steroidei sessuali nel cancro del fegato e del colon. Negli ultimi due decenni sono state condotte diverse linee di ricerca. Numerosi studi sperimentali, coinvolgendo anche topi geneticamente manipolati, sono stati condotti sia nel campo del carcinoma epatocellulare che del cancro del colon-retto. Inoltre, è stato studiato il ruolo degli ormoni steroidei sessuali nello sviluppo di queste malattie neoplastiche. Gli studi sul carcinoma epatocellulare hanno incluso l'applicazione di metodologie sperimentali con implicazioni traslazionali e la valutazione dei fattori di rischio; inoltre, l'attività di ricerca si è concentrata sui benefici e sugli aspetti critici delle terapie mediche e locoregionali per l'epatocarcinoma. Per completare la descrizione dell'attività di ricerca in epatologia, sono stati pubblicati numerosi studi sulle complicanze e sulla terapia correlate al virus dell'epatite C, sulla terapia del virus dell'epatite B e sulle implicazioni cliniche di questa infezione virale in pazienti sottoposti a terapie immunosoppressive. Infine, diverse pubblicazioni hanno considerato diversi aspetti nel contesto del trapianto di fegato, comprese le politiche di allocazione degli organi. Sono stati pubblicati diversi studi sugli aspetti nutrizionali concentrandosi specificamente sulle implicazioni della nutrizione artificiale, aspetti clinici e nutrizionali nel trapianto di fegato, nutrizione e composizione corporea, aspetti nutrizionali nelle malattie neurodegenerative, potenziali applicazioni terapeutiche della modificazione del microbiota intestinale mediante manipolazioni dietetiche, inclusa la celiachia. La ricerca sulla cancerogenesi del colon ha portato allo sviluppo di un brevetto italiano n. BA2008A000008 per conto di LEO ALFREDO e BARONE MICHELE dal titolo "Composizioni comprendenti fitoestrogeni selettivi per il recettore beta degli estrogeni e fibre alimentari".L’attività di ricerca sull’influenza degli ormoni steroidei sessuali sui tumori del colon retto ha portato, nel 2008, allo sviluppo di un brevetto italiano n. BA2008A000008 a nome di DI LEO ALFREDO e BARONE MICHELE dal titolo "Composizioni comprendenti fitoestrogeni selettivi per il recettore estrogenico beta e fibre dietetiche"