Pubblicazioni

Prof. Cosimo Damiano Altomare

Dipartimento di Farmacia-Scienze del Farmaco

Università degli Studi di Bari Aldo Moro

PUBLICATIONS

Articles and reviews in journals

  1. CARRIERI A., BARBAROSSA A., DE CANDIA M., SAMARELLI F., ALTOMARE C.D., CZARNOTA-ŁYDKA K., SUDOŁ-TAŁAJ S., LATACZ G., HANDZLIK J., BRUNETTI L., PIEMONTESE L., LIMONGELLI F., LENTINI G., CAROCCI A. (2024) Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases. BIOORGANIC AND MEDICINAL CHEMISTRY, 110, 117829.

  2. SAMARELLI F., PURGATORIO R., LOPOPOLO G., DERUVO C., CATTO M., ANDRESINI M., CARRIERI A., NICOLOTTI O., DE PALMA A., MINIERO D.V., DE CANDIA M., ALTOMARE C.D. (2024) Novel 6-alkyl-bridged 4- arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 270, 116353.

  3. NEVSKAYA, A.A., PURGATORIO, R., BORISOVA, T.N., VARLAMOV, A.V., ANIKINA, L.V., OBYDENNIK, A.Y., NEVSKAYA, E.Y., NISO, M., COLABUFO, N.A., CARRIERI, A., CATTO, M., DE CANDIA, M., VOSKRESSENSKY, L.G., ALTOMARE, C.D. (2024) Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein- Dependent Multidrug Resistance. PHARMACEUTICALS, 17 (4), 539.

  4. MUGNAINI C., BRIZZI A., PAOLINO M., SCARSELLI E., CASTELLI R., DE CANDIA M., GAMBACORTA N., NICOLOTTI O., KOSTRZEWA M., KUMAR P., MAHMOUD A.M., BORGONETTI V., IANNOTTA M., MORACE A., GALEOTTI N., MAIONE S., ALTOMARE C.D., LIGRESTI A., CORELLI F. (2024). Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo ACS CHEMICAL NEUROSCIENCE, 15 (5), pp. 955-971.

  5. SBLANO S., BOCCARELLI A., MESITI F., PURGATORIO R., DE CANDIA M., CATTO M., ALTOMARE C.D. (2024) A second life for MAO inhibitors? From CNS diseases to anticancer therapy. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 267, 116180.

  6. SAMARELLI F., GRAZIANO G., GAMBACORTA N., GRAPS E.A., LEONETTI F., NICOLOTTI O., ALTOMARE C.D. (2024) Small Molecules for the Treatment of Long-COVID-Related Vascular Damage and Abnormal Blood Clotting: A Patent-Based Appraisal. VIRUSES, 16 (3), 450.

  1. LEE S.H., PURGATORIO R., SAMARELLI F., CATTO M., DENORA N., MORGESE M.G., TUCCI P., TRABACE L., KIM H.W., PARK H.S., KIM S.E., LEE B.C., DE CANDIA M., ALTOMARE C.D. (2024) Radiosynthesis and whole-body distribution in mice of a 18F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease. ARCHIV DER PHARMAZIE, 357 (3), 2300491.

  2. MASTROLORITO F., TOGO M.V., GAMBACORTA N., TRISCIUZZI D., GIANNUZZI V., BONIFAZI F., LIANTONIO A., IMBRICI P., DE LUCA A., ALTOMARE C.D., CIRIACO F., AMOROSO N., NICOLOTTI O. (2024). TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity. CHEMICAL RESEARCH IN TOXICOLOGY, 37(2), pp. 323-339.

  3. PURGATORIO R., BOCCARELLI A., PISANI L., DE CANDIA M., CATTO M., ALTOMARE C.D. (2024) A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics. ANTIOXIDANTS, 13 (1), 133.

  4. TOGO M.V., MASTROLORITO F., ORFINO A., GRAPS, E.A., TONDO A.R., ALTOMARE C.D., CIRIACO F., TRISCIUZZI D., NICOLOTTI O., AMOROSO N. (2024). Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives. EXPERT OPINION ON DRUG METABOLISM AND TOXICOLOGY, 20(7), pp. 561-577.

  5. IMBRICI P., D’ORSI G., CARELLA M., NICOLOTTI O., DE LUCA A., ALTOMARE C.D., LIANTONIO A. (2024) Sodium-glucose cotransporter-2 inhibitors: A potential novel treatment for Lafora disease? PHARMACOLOGICAL RESEARCH, 199, 107012.

  6. MELE M., IMBRICI P., MELE A., TOGO M.V., DINOI G., CORREAL M., BRUNETTI N.D., NICOLOTTI O., DE LUCA A., ALTOMARE C.D., LIANTONIO A., AMOROSO N. (2023). Short-term anti-remodeling effects of gliflozins in diabetic patients with heart failure and reduced ejection fraction: an explainable artificial intelligence approach (2023). FRONTIERS IN PHARMACOLOGY 14, 1175606.

  7. AMOROSO N., GAMBACORTA N., MASTROLORITO F., TOGO M.V., TRISCIUZZI D., MONACO A., PANTALEO E., ALTOMARE C.D., CIRIACO F., NICOLOTTI O. (2023). Making sense of chemical space network shows signs of criticality. SCIENTIFIC REPORTS 13, 21335.

  8. DE CANDIA M., TITOV A.A., VIA YNA A., KULIKOV A L.N., PURGA TORIO R., PIERGIOVANNI B., NISO M., CATTO M., VOSKRESSENSKY L.G., LUQUE J.F., ALTOMARE C.D. (2023). In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase. CHEMICO-BIOLOGICAL INTERACTIONS, 386, 110741.

  1. CZARNOTA-ŁYDKA K., SUDOŁ-TAŁAJ S., KUCWAJ-BRYSZ K., KURCZAB R., SATAŁA G., DE CANDIA M, SAMARELLI F., ALTOMARE C.D., CAROCCI A., BARBAROSSA A., ESŁAWSKA E.Z., GŁUCH-LUTWIN F., MORDYL B., KUBACKA M., WILCZY ́NSKA-ZAWAL M., JASTRZĘBSKA-WIĘSEK M., PARTYKA A., KHAN N., WIĘCEK M., NITEK W., HONKISZ-ORZECHOWSKA E., LATACZ E., WESOŁOWSKA A., CARRIERI A., HANDZLIK J. (2023). Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 259, 115695.

  2. GAMBACORTA N., CIRIACO F., AMOROSO N., ALTOMARE C.D., BAJORATH J., NICOLOTTI O. (2023). CIRCE: Web-Based Platform for the Prediction of Cannabinoid Receptor Ligands Using Explainable Machine Learning. JOURNAL OF CHEMICAL INFORMATION AND MODELING 63, pp. 5916-5926.

  3. PAOLINO M., DE CANDIA M., PURGATORIO R., CATTO M., SALETTI M., TONDO A.R., NICOLOTTI O., CAPPELLI A., BRIZZI A., MUGNAINI C., CORELLI F., ALTOMARE C.D. (2023). Investigation on Novel E/Z 2- Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity. MOLECULES 28, 5857.

  4. SCHINO I., CANTORE M., DE CANDIA M., ALTOMARE C.D., MARIA C., BARROS J., CACHATRA V., CALADO P., SHIMIZU K., FREITAS A.A., OLIVEIRA M.C., FERREIRA M.J., LOPES J.N.C., COLABUFO N.A., RAUTER A.P. (2023) Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease. PHARMACEUTICALS, 16, 54.

  5. TOGO M.V., MASTROLORITO F., CIRIACO F., TRISCIUZZI D., TONDO A.R., GAMBACORTA N., BELLANTUONO L., MONACO A., LEONETTI F., BELLOTTI R., ALTOMARE C.D., AMOROSO N., NICOLOTTI O. (2023) TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 63, pp. 56-66.

  6. KULIKOVA L.N., RAESI G.R., LEVICKAYA D.D., PURGATORIO R., SPADA G.L., CATTO M., ALTOMARE C.D., VOSKRESSENSKY L.G. (2023) Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors. MOLECULES, 28, 1662

  7. KULIKOVA L.N., PURGATORIO R., BELOGLAZKIN A.A., TAFEENKO V.A., REZA R.G., LEVICKAYA D.D., SBLANO S., BOCCARELLI A., DE CANDIA M., CATTO M., VOSKRESSENSKY L.G., ALTOMARE C.D. (2023). Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, 7724.

  1. PAOLINO M., RULLO M., MARAMAI S., DE CANDIA M., PISANI L., CATTO M., MUGNAINI C., BRIZZI A., CAPPELLI A., OLIVUCCI M., CORELLI F., ALTOMARE C.D. (2022). Design, synthesis and biological evaluation of light- driven on-off multitarget AChE and MAO-B inhibitors. RSC MEDICINAL CHEMISTRY, vol. 13, pp. 873-883

  2. LOPALCO A., MANNI A., KEELEY A., HAIDER S., LI W., LOPEDOTA A., ALTOMARE C.D., DENORA N., TULEU C. (2022) In Vivo Investigation of (2- Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in Aqueous Solution for Paediatric Use. PHARMACEUTICS, vol. 14, 780.

  3. KOBZEV, M.S., TITOV, A.A., ALEXANDROVA, E.V., PURGATORIO, R., CATTO, M., SOROKINA, E.A., BORISOVA, T.N., VARLAMOV, A.V., ALTOMARE, C.D., VOSKRESSENSKY, L.G. (2022) Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors. MOLECULAR DIVERSITY, vol. 26, pp. 1243-1247

  4. RULLO M., CIPOLLONI M., CATTO M., COLLIVA C., MINIERO D.V., LATRONICO T., DE CANDIA M., BENICCHI T., LINUSSON A., GIACCHÈ N., ALTOMARE C.D., PISANI L. (2022) Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies. JOURNAL OF MEDICINAL CHEMISTRY, vol. 65, pp. 3962-3977.

  5. BOLOGNINO I., CARRIERI A., PURGATORIO R., CATTO M., CALIANDRO R., CARROZZINI B., BELVISO B.D., MAJELLARO M., SOTELO E., CELLAMARE S., ALTOMARE C.D. (2022) Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase. SEPARATIONS, vol. 9, 7.

  6. PURGATORIO R., GAMBACORTA N., SAMARELLI F., LOPOPOLO G., DE CANDIA M., CATTO M., NICOLOTTI O., ALTOMARE C.D. (2022). Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases. MOLECULES, 27, 4269.

  7. BRUNETTI L., LEUCI R., CARRIERI A., CATTO M., OCCHINERI S., VINCI G., GAMBACORTA L., BALTRUKEVICH H., CHAVES S., LAGHEZZA A., ALTOMARE C.D., TORTORELLA P., SANTOS M.A., LOIODICE F., PIEMONTESE L. (2022). Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 237, 114358.

  8. DE MAIO F., RULLO M., DE CANDIA M., PURGATORIO R., LOPOPOLO G., SANTARELLI G., PALMIERI V., PAPI M., ELIA G., DE CANDIA E.,SANGUINETTI M., ALTOMARE C.D. (2022). Evaluation of Novel Guanidino- Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection. VIRUSES, 14, 1730.

  1. CAROCCI A., BARBAROSSA A., LEUCI R., CARRIERI A., BRUNETTI L., LAGHEZZA A., CATTO M., LIMONGELLI F., CHAVES S., TORTORELLA P., ALTOMARE C.D., SANTOS M.A., LOIODICE F., PIEMONTESE L. (2022). Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease. ANTIOXIDANTS, 11, 1631

  2. TITOV A.A., PURGATORIO R., OBYDENNIK A.Y., LISTRATOVA A.V., BORISOVA T.N., DE CANDIA M., CATTO M., ALTOMARE C.D., VARLAMOV A.V., VOSKRESSENSKY L.G. (2022). Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity. MOLECULES, 27, 6276.

  3. PISANI L., CATTO M., MUNCIPINTO G., NICOLOTTI O., CARRIERI A., RULLO M., STEFANACHI A., LEONETTI F., ALTOMARE C. (2022). A twenty- year journey exploring coumarin-based derivatives as bioactive molecules. FRONTIERS IN CHEMISTRY, 10, 1002547.

  4. BRINDISI M., FRATTARUOLO L., MANCUSO R., PALUMBO PICCIONELLO A., ZICCARELLI I., CATTO M., NICOLOTTI O., ALTOMARE C.D., GABRIELE N., CAPPELLO A.R. (2021) Anticancer potential of novel α,β-unsaturated γ- lactam derivatives targeting the PI3K/AKT signaling pathway. BIOCHEMICAL PHARMACOLOGY, vol. 190, 114659.

  5. PURGATORIO R., DE CANDIA M., CATTO M., RULLO M., PISANI L., DENORA N., CARRIERI A., NEVSKAYA A.A., VOSKRESSENSKY L.G., ALTOMARE C.D. (2021) Evaluation of Water-Soluble Mannich Base Prodrugs of 2,3,4,5-Tetrahydroazepino[4,3-b]indol-1(6H)-one as Multitarget-Directed Agents for Alzheimer's Disease. CHEMMEDCHEM, vol 16, 589-598.

  6. MANCUSO R., ZICCARELLI I., BRINDISI M., ALTOMARE C.D., FRATTARUOLO L., FALCICCHIO A., DELLA CA' N., CAPPELLO A.R., GABRIELE B. (2021) A stereoselective, multicomponent catalytic carbonylative approach to a new class of α,β-unsaturated γ-lactam derivatives. CATALYSTS, vol. 11, 1-18.

  7. TITOV A.A., KOBZEV M.S., CATTO M., DE CANDIA M., GAMBACORTA N., DENORA N., PISANI L., NICOLOTTI O., BORISOVA T.N., VARLAMOV A.V., VOSKRESSENSKY L.G., ALTOMARE C.D. (2021) Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents. ACS CHEMICAL NEUROSCIENCE, vol. 12, 340-353.

  1. BOLOGNINO I., GIANGREGORIO N., TONAZZI A., MARTINEZ A.L., ALTOMARE C.D., LOZA M.I., SABLONE S., CELLAMARE S., CATTO M. (2021) Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases. CHEMMEDCHEM, vol. 16, 2807-2816.

  2. NEVSKAYA A. A., ANIKINA L. V., PURGATORIO R., CATTO M., NICOLOTTI O., DE CANDIA M., PISANI L., BORISOVA T. N., MIFTYAKHOVA A. R., VARLAMOV A. V., NEVSKAYA E. Y., BORISOV R. S., VOSKRESSENSKY L. G., ALTOMARE C.D. (2021). Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti- Alzheimer's Disease Potential. MOLECULES, VOL. 26, ISSN: 1420-3049, DOI: 10.3390/molecules26020359

  3. GUIEU B., LECOUTEY C., LEGAY R., DAVIS A., DE OLIVEIRA SANTOS J.S., ALTOMARE C.D., CATTO M., ROCHAIS C., DALLEMAGNE P. (2021) First synthesis of racemic trans propargylamino-donepezil, a pleiotrope agent able to both inhibit AChE and MAO-B, with potential interest against Alzheimer’s disease. MOLECULES, vol. 26, 80.

  4. PURGATORIO R., GAMBACORTA N., CATTO M., DE CANDIA M., PISANI L., ESPARGARÓ A., SABATÉ R., CELLAMARE S., NICOLOTTI O., ALTOMARE C.D. (2020) Pharmacophore modeling and 3D-QSAR study of indole and isatin derivatives as antiamyloidogenic agents targeting Alzheimer's disease. MOLECULES, vol. 25, 5773.

  5. COCO L.D., MAJELLARO M., BOCCARELLI A., CELLAMARE S., ALTOMARE C.D., FANIZZI, F.P. (2020) Novel antiproliferative biphenyl nicotinamide: NMR metabolomic study of its effect on the MCF-7 cell in comparison with cisplatin and vinblastine. MOLECULES, vol. 15, 3502.

  6. PURGATORIO R., KULIKOVA L.N., PISANI L., CATTO M., DE CANDIA M., CARRIERI A., CELLAMARE S., DE PALMA A., BELOGLAZKIN A.A., REZA RAESI G., VOSKRESSENSKY L.G., ALTOMARE C.D. (2020) Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets. CHEMMEDCHEM, vol. 15, 1947-1955.

  7. YUE X., FESTA A.A., STOROZHENKO O.A., VARLAMOV A.V., SUBRAMANI K., BOCCARELLI A., PURGATORIO R., ALTOMARE C.D., VOSKRESSENSKY L.G. (2020) Reductive domino reaction to access chromeno[2,3-c]isoquinoline-5- amines with antiproliferative activities against human tumor cells. BIOORGANIC CHEMISTRY, vol. 104, 104169.

  8. CATTO M., PISANI L., DE LA MORA E., BELVISO B.D., MANGIATORDI G.F., PINTO A., DE PALMA A., DENORA N., CALIANDRO R., COLLETIER J.-P., SILMAN I., NICOLOTTI O., ALTOMARE C.D. (2020). Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor. ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, p. 869-876.

  1. VIAYNA A., ANTERMITE S.G., DE CANDIA, M., ALTOMARE C.D., LUQUE F.J. (2020). Interplay between Ionization and Tautomerism in Bioactive β- Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6- Tetrahydroazocine Derivatives. JOURNAL OF PHYSICAL CHEMISTRY B, vol. 124, p. 28-37.

  2. PASCULLI A., GURRADO A., DE LUCA G.M., MELE A., MARZULLO A., MANGONE A., CELLAMARE S., FERRARO V., MAQOUD F., CAGGIANI M.C., RANA F., CAVALLARO G., PRETE F.P., TRICARICO D., ALTOMARE C.D., TESTINI M. (2020). Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes. SCIENTIFIC REPORTS, vol. 10, p. 6959.

  3. RULLO M., NISO M., PISANI L., CARRIERI A., COLABUFO N.A., CELLAMARE S., ALTOMARE C.D. (2019). 1,2,3,4-Tetrahydroisoquinoline/2H- chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 161, p. 433-444, ISSN: 0223-5234, doi: 10.1016/j.ejmech.2018.10.043

  4. MATVEEVA M.D., PURGATORIO R., VOSKRESSENSKY L.G., ALTOMARE C.D. (2019). Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry. FUTURE MEDICINAL CHEMISTRY, vol. 11, p. 2735-2755.

  5. TITOV A.A., NISO M., CANDIA M., KOBZEV M.S., VARLAMOV A.V., BORISOVA T.N., VOSKRESSENSKY L.G., COLABUFO N.A., CELLAMARE S., PISANI L., ALTOMARE C.D. (2019). 3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance. FUTURE MEDICINAL CHEMISTRY, vol. 11, p. 2095-2106, ISSN: 1756-8919, doi: 10.4155/fmc-2019-0037

  6. BOLOGNINO I., GIANGREGORIO N., PISANI L., DE CANDIA M., PURGATORIO R., TONAZZI A., ALTOMARE C.D., CELLAMARE S., CATTO M. (2019). A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease. MOLECULES, vol. 24, 4298, doi: 10.3390/molecules24234298

  7. RULLO M., CATTO M., CARRIERI A., DE CANDIA M., ALTOMARE C.D., PISANI L. (2019). Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7- Benzyloxy-2H-Chromen-2-ones. MOLECULES, vol. 24, doi: 10.3390/ molecules24244507

  1. PURGATORIO R., DE CANDIA M., CATTO M., CARRIERI A., PISANI L., DE PALMA A., TOMA M., IVANOVA O. A., VOSKRESSENSKY L.G., ALTOMARE C.D. (2019). Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 177, p. 414-424, ISSN: 0223-5234, doi: 10.1016/j.ejmech.2019.05.062

  2. PISANI L., IACOBAZZI R.M., CATTO M., RULLO M., FARINA R., DENORA N., CELLAMARE S., ALTOMARE C.D. (2019). Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 161, p. 292-309, ISSN: 0223-5234, doi: 10.1016/j.ejmech.2018.10.016.

  3. NEVSKAYA A.A., MATVEEVA M.D., BORISOVA T.N., NISO M., COLABUFO N.A., BOCCARELLI A., PURGATORIO R., DE CANDIA M., CELLAMARE S., VOSKRESSENSKY L.G., ALTOMARE C.D. (2018). A New Class of 1-Aryl-5,6- dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein- Mediated Multidrug Resistance in Tumor Cells. CHEMMEDCHEM, vol. 15, p. 1588-1596, DOI: 10.1002/cmdc.201800177.

  4. PISANI L., RULLO M., CATTO M., DE CANDIA M., CARRIERI A., CELLAMARE S., ALTOMARE C.D. (2018). Structure–property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1- alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase. JURNAL OF SEPARATION SCIENCE, vol. 41, p. 1376-1384, DOI: 10.1002/jssc.201701442.

  5. PURGATORIO R., DE CANDIA M., DE PALMA A., DE SANTIS F., PISANI L., CAMPAGNA F., CELLAMARE S., ALTOMARE C.D., CATTO M. (2018). Insights into structure-activity relationships of 3-arylhydrazonoindolin-2-one derivatives for their multitarget activity on β-amyloid aggregation and neurotoxicity. MOLECULES, vol. 23, p. 1544, DOI: 10.3390/molecules23071544.

  6. PISANI L., DE PALMA A., GIANGREGORIO N., MINIERO D.V., PESCE P., NICOLOTTI O., CAMPAGNA F., ALTOMARE C.D., CATTO M. (2017). Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water- soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, p. 381-388, DOI: 10.1016/j.ejps.2017.08.004.

  7. LEE B.C., MOON B.S., PARK H.S., JUNG J.H., PARK H.S., PARK D.D., DE CANDIA M., DENORA N., ALTOMARE C.D., KIM S.E. (2017). The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 109, p. 209-216. DOI: 10.1016/j.ejps.2017.08.008

  8. CASSANO T., LOPALCO A., DE CANDIA M., LAQUINTANA V., LOPEDOTA A., CUTRIGNELLI A., PERRONE M., IACOBAZZI R.M., BEDSE G., FRANCO M., DENORA N., ALTOMARE C.D. (2017). Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats. MOLECULAR PHARMACEUTICS, vol. 14, p. 3178-3187. DOI: 10.1021/ acs.molpharmaceut.7b00405
  9. ALTOMARE C.D. (2017) Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 53, p. 239-239. DOI: https://doi.org/10.1007/s10593-017-2046-4

  1. DE CANDIA M., ALTAMURA C., DENORA N., CELLAMARE S., NUZZOLESE M., DE VITO D., VOSKRESSENSKY L.G., VARLAMOV A.V., ALTOMARE C.D. (2017). Physicochemical properties and antimicrobial activity of new spirocyclic thieno[2,3-d]pyrimidin-4(3H)-one derivatives. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 53, p. 357-363. DOI: 10.1007/s10593-017- 2057-1

  2. DENORA N., LOPEDOTA A., DE CANDIA M., CELLAMARE S., DEGENNARO L., LUISI R., MELE A., TRICARICO D., CUTRIGNELLI A., LAQUINTANA V., ALTOMARE C.D., FRANCO M., DIMICCOLI V., TOLOMEO A., SCILIMATI A. (2017). Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99, p. 361-368. DOI: 10.1016/j.ejps.2016.10.001

  3. PISANI L., CATTO M., DE PALMA A., FARINA R., CELLAMARE S., ALTOMARE C.D. (2017). Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin- Based Moieties. CHEMMEDCHEM, vol. 12, p. 1349-1358. DOI: 10.1002/cmdc.201700282

  4. DE CANDIA M., ZAETTA G., DENORA N., TRICARICO D., MAJELLARO M., CELLAMARE S., ALTOMARE C.D. (2017). New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 125, p. 288-298. DOI: 10.1016/j.ejmech.2016.09.037

  5. PARISI G., DEGENNARO L., CARLUCCI C., DE CANDIA M., MASTRORILLI P., ROLLER A., HOLZER W., ALTOMARE C.D., PACE V., LUISI R. (2017). A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles. ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 15, p. 5000- 5015. DOI: 10.1039/c7ob00846e

  1. MAJELLARO M., STEFANACHI A., TARDIA P., VICENTI C., BOCCARELLI A., PANNUNZIO A., CAMPANELLA F., COLUCCIA M., DENORA N., LEONETTI F., DE CANDIA M., ALTOMARE C.D., CELLAMARE S. (2017). Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides. CHEMMEDCHEM, vol. 12, p. 1380-1389. DOI: 10.1002/cmdc.201700365

  2. PISANI L., FARINA R., CATTO M., IACOBAZZI R.M, NICOLOTTI O., CELLAMARE S., MANGIATORDI G.F., DENORA N., SOTO-OTERO R., SIRAGUSA L., ALTOMARE C.D., CAROTTI, A. (2016). Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, p. 6791-6806.

  3. D’ANDRIA P., GIANNUZZI V., BONIFAZI F., CECI A., DENORA N., ALTOMARE C.D. (2016). Formulating medicines for children: Challenges and issues. LA CHIMICA E L’INDUSTRIA, 3, 16-21.

  4. PISANI L., FARINA R., SOTO-OTERO R., DENORA N., MANGIATORDI G.F., NICOLOTTI O., MENDEZ-ALVAREZ E., ALTOMARE C.D., CATTO M., CAROTTI, A. (2016). Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif. MOLECULES, vol. 21, 362-377.

  5. MANGIATORDI G. F., ALBERGA D., ALTOMARE C. D., CAROTTI A., CATTO M., CELLAMARE S., GADALETA D., LATTANZI G., LEONETTI F., PISANI L., STEFANACHI A., TRISCIUZZI D. NICOLOTTI O. (2016). Mind the Gap! A Journey towards Computational Toxicology. MOLECULAR INFORMATICS vol. 35, 294-308. doi: 10.1002/minf.201501017

  6. FARINA R., PISANI L., CATTO M., NICOLOTTI O., GADALETA D., DENORA N., SOTO-OTERO R., MENDEZ-ALVAREZ E., PASSOS C.S., MUNCIPINTO G., ALTOMARE C.D., NURISSO A., CARRUPT P.A., CAROTTI A. (2015). Structure- Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases. JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, p. 5561-5578.

  7. LEO V., STEFANACHI A., NACCI C., LEONETTI F., DE CANDIA M., CAROTTI A., ALTOMARE C.D., MONTAGNANI M., CELLAMARE S. (2015). Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c- Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 67, p. 1380-92.

  1. MIDZAK A., DENORA N., LAQUINTANA V., CUTRIGNELLI A., LOPEDOTA A., FRANCO M., ALTOMARE C.D., PAPADOPOULOS V. (2015). 2- Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 76, p. 231-237.

  2. DE CANDIA M., MARINI E., ZAETTA G., CELLAMARE S., DI STILO A., ALTOMARE C. (2015). New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 72, p. 69-80.

  3. FARINA R., PISANI L., CATTO M., NICOLOTTI O., GADALETA D., DENORA N., SOTO-OTERO R., MENDEZ-ALVAREZ E., PASSOS C.S., MUNCIPINTO G., ALTOMARE C.D., NURISSO A., CARRUPT P.-A., CAROTTI A. (2015). Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen- 2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases. JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, p. 5561-5578.

  4. BELVISO B.D., CALIANDRO R., DE CANDIA M., ZAETTA G., LOPOPOLO G., INCAMPO F., COLUCCI M., ALTOMARE C. (2014). How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2- Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties. JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, p. 8563-8575.

  5. DE CANDIA M., FIORELLA F., LOPOPOLO G., CAROTTI A., ROMANO M.R., LOGRANO M.D., MARTEL S., CARRUPT P.-A., BELVISO B.D., CALIANDRO R., ALTOMARE C. (2013). Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4‐(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, p. 8696-8711.

  6. PISANI L., BARLETTA M., SOTO-OTERO R., NICOLOTTI O., MENDEZ- ALVAREZ E., CATTO M., INTROCASO A., STEFANACHI A., CELLAMARE S., ALTOMARE C., CAROTTI A. (2013). Discovery, Biological Evaluation, and Structure-Activity and -Selectivity Relationships of 6’-Substituted (E)-2- (Benzofuran-3(2H)-ylidene)-N-methylacetamides, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, p. 2651-2664.

  7. CALIANDRO R., BELVISO D.B., ARESTA B.M., DE CANDIA M., ALTOMARE C. (2013). Protein crystallography and fragment-based drug design. FUTURE MEDICINAL CHEMISTRY, vol. 5, p. 1121-1140.

  8. VOSKRESSENSKY L.G., KOVALEVA S.A., BORISOVA T.N., ERESKO A.B., TOLKUNOV V.S., TOLKUNOV S.V., LISTRATOVA A.V., DE CANDIA M., ALTOMARE C., VARLAMOV A.V. (2013). Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 49, p. 930-940.

  1. SOTO-OTERO R., MENDEZ-ALVAREZ E., SANCHEZ-IGLESIAS S., LABANDEIRA J.L., RODRIGUEZ-PALLARES J., ZUBKOV F.I., ZAITSEV V.P., VOSKRESSENSKY G., VARLAMOV V., DE CANDIA M., FIORELLA F., ALTOMARE C. (2012). 2-Benzazepine Nitrones Protect Dopaminergic Neurons Against 6-Hydroxydopamine-Induced Oxidative Toxicity. ARCHIV DER PHARMAZIE, vol. 2012, p. 598-609.

  2. STEFANACHI A., LEONETTI F., NICOLOTTI O., CATTO M., PISANI L., CELLAMARE S., ALTOMARE C., CAROTTI A. (2012). New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia. CURRENT CANCER DRUG TARGETS, vol. 12, p. 571-596.

  3. LOPOPOLO G., DE CANDIA M., PANZA L., ROMANO M.R., LOGRANO M.D., CAMPAGNA F., ALTOMARE C. (2012). beta-D-Glucosyl Conjugates of Highly Potent Inhibitors of Blood Coagulation Factor Xa Bearing 2-Chorothiophene as P1 Motif. CHEMMEDCHEM, vol. 7, p. 1669-1677.

  4. LOPOPOLO G, FIORELLA F, DE CANDIA M, NICOLOTTI O, MARTEL S, CARRUPT P.-A, ALTOMARE C. (2011). Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 42, p. 180-191.

  5. CAMPAGNA F, CATTO M, PURGATORIO R, ALTOMARE C., CAROTTI A, DE STRADIS A, PALAZZO G (2011). Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, p. 275-284.

  6. DE CANDIA M, LIANTONIO F, CAROTTI A, DE CRISTOFARO R, ALTOMARE C. (2009). Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52; p. 1018-1028.

  7. DE CANDIA M, LOPOPOLO G, ALTOMARE C. (2009). Novel factor Xa inhibitors: A patent review. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 19; p. 1535-1580.

  8. SOTO-OTERO R, MENDEZ-ALVAREZ E, SANCHEZ-IGLESIAS S, ZUBKOV F, VOSKRESSENSKY L. G, VARLAMOV A. V, DE CANDIA M, ALTOMARE C. (2008). Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5- dihydro-3H-2-benzazepine N-oxides. BIOCHEMICAL PHARMACOLOGY, vol. 75; p. 1526-1537.

  1. CAROTTI A, CATTO M, LEONETTI F, CAMPAGNA F, SOTO-OTERO R, MENDEZ-ALVAREZ E, THULL U, TESTA B, ALTOMARE C. (2007). Synthesis and Monoamine Oxidase Inhibitory Activity of New Pyridazine-, Pyrimidine- and 1,2,4-Triazine-Containing Tricyclic Derivatives. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50; p. 5364-5371.

  2. CAROTTI A., ALTOMARE C., CATTO M., GNERRE C., SUMMO L., DE MARCO A., ROSE S., JENNER P., TESTA B. (2006). Lipophilicity Plays a Major Role in Modulating the Inhibition of Monoamine Oxidase B by 7-Substituted Coumarins. CHEMISTRY & BIODIVERSITY, vol. 3; p. 134-149.

  3. CAROTTI A, DE CANDIA M, CATTO M, BORISOVA T.N, VARLAMOV A.V, MENDEZ-ALVAREZ E, SOTO-OTERO R, VOSKRESSENSKY L.G, ALTOMARE C. (2006). Ester Derivatives of Annulated Tetrahydroazocines: A New Class of Selective Acetylcholinesterase Inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14; p. 7205-7512.

  4. DE CRISTOFARO R., CAROTTI A., AKHAVAN S., PALLA R., PEYVANDI F., ALTOMARE C., MANNUCCI P.M. (2006). The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, theoverall enzyme’s stability and conformational transitions linked to Na+ binding. THE FEBS JOURNAL, vol. 273; p. 159-169.

  5. DE CANDIA M., FOSSA P., CELLAMARE S., MOSTI L., CAROTTI A., ALTOMARE C. (2005). Insights into Structure-Activity Relationships from Lipophilicity Profiles of Pyridin-2(1H)-one Analogs of the Cardiotonic Agent Milrinone. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 26; p. 78-86.

  6. DE CRISTOFARO R., AKHAVAN S., ALTOMARE C., CAROTTI A., PEYVANDI F., MANNUCCI P.M. (2004). A natural prothrombin mutant reveals an unexpected influence of the A-chain’s structure on the activity of human alpha- thrombin. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279; p. 13035- 13043.

  7. DE MARCO A., DE CANDIA M., CAROTTI A., CELLAMARE S., DE CANDIA E., ALTOMARE C. (2004). Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 22; p. 153-164.

  8. NICOLOTTI O., ALTOMARE C., PELLEGRINI-CALACE M., CAROTTI A. (2004). Neuronal Nicotinic Acetylcholine Receptor Agonists: Pharmacophores, Evolutionary QSAR and 3D-QSAR models. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 4; p. 335-360.

  9. VOSKRESSENSKY L.G., BORISOVA T.N., KULIKOVA L.N., VARLAMOV A.V., CATTO M., ALTOMARE C., CAROTTI A. (2004). Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 14; p. 3128-3135.

  1. ALTOMARE C., TRAPANI G., LATROFA A., SERRA M., SANNA E., BIGGIO G, LISO G. (2003). Water-soluble derivatives of the anesthetic agent propofol: In vitro and in vivo evaluation of cyclic amino acid esters. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 20; p. 17-26.

  2. CAROTTI A., ALTOMARE C., SAVINI L., CHIASSERINI L., PELLERANO C., MASCIA M.P., MACIOCCO E., BUSONERO F., MAMELI M., BIGGIO G., SANNA E. (2003). High Affinity Central Benzodiazepine Receptor Ligands. Part 3: Insights into the Pharmacophore and Pattern Recognition Study of Intrinsic Activities of Pyrazolo[4,3-c]quinolin-3-ones. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11; p. 5259-5272.

  3. DE CANDIA M., SUMMO L., CARRIERI A., ALTOMARE C., NARDECCHIA A., CELLAMARE S., CAROTTI A. (2003). Investigation of Platelet Aggregation Inhibitory Activity by Phenyl Amides and Esters of Piperidinecarboxylic Acids. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11; p. 1439-1450.

  4. VOSKRESSENSKY L. G., DE CANDIA M., CAROTTI A., BORISOVA T. N., KULIKOVA L. N., VARLAMOV A. V., ALTOMARE C. (2003). Investigation on the Antiplatelet Activity of Pyrrolo[3,2-c]pyridine-Containing Compounds. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 55.

  5. ASPRONI B., PAU A., MACIOCCO E., SANNA E., ALTOMARE C., TRAPANI G., BIGGIO G., ET AL. (2002). Synthesis and Pharmacological Evaluation of 1- [(1,2-Diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with Clozapine- Like Mixed Activities at Dopamine D2, Serotonin, and GABAA Receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 45; p. 4655-4668.

  6. CARRIERI A., CAROTTI A., BARRECA M.L., ALTOMARE C. (2002). Binding Models of Reversible Inhibitors of Type-B Monoamine Oxidase. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, vol. 16; p. 769-778.

  7. NICOLOTTI O., PELLEGRINI-CALACE M., ALTOMARE C., CAROTTI A., SANZ F. (2002). Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models. CURRENT MEDICINAL CHEMISTRY, vol. 9; p. 1-29.

  8. BRÜHLMANN C., OOMS F., CARRUPT P.-A., TESTA B., CATTO M., LEONETTI F., ALTOMARE C., CAROTTI A. (2001). Coumarin derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. JOURNAL OF MEDICINAL CHEMISTRY, vol. 44; p. 3195-3198, ISSN: 0022-2623

  1. NICOLOTTI O., PELLEGRINI P.L., CARRIERI A., ALTOMARE C., CENTENO N.B., SANZ F., CAROTTI A. (2001). Neuronal Nicotinic Agonists: a Multi- approach Development of the Pharmacophore. JOURNAL OF COMPUTER- AIDED MOLECULAR DESIGN, vol. 15; p. 859-872.

  2. SAVINI L., CHIASSERINI L., PELLERANO C., BIGGIO G., MACIOCCO E., SERRA M., CINONE N., CARRIERI A., ALTOMARE C., CAROTTI A. (2001). High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9; p. 431-444.

  3. ALTOMARE C., CELLAMARE S., SUMMO L., FOSSA P., MOSTI L., CAROTTI A. (2000). Ionization Behaviour and Tautomerism-Dependent Lipophilicity of Pyridine-2(1H)-one Cardiotonic Agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8; p. 909-916.

  4. ALTOMARE C., SUMMO L., CELLAMARE S., VARLAMOV A.V., VOSKRESSENSKY L.G., BORISOVA T.N., CAROTTI A. (2000). Pyrrolo[3,2- c]pyridine derivatives as inhibitors of platelet aggregation. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 10; p. 581-584.

  5. GNERRE C., CATTO M., LEONETTI F., WEBER P., CARRUPT P.-A., ALTOMARE C., CAROTTI A., TESTA B. (2000). Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43; p. 4747-4758.

  6. TRAPANI G., ALTOMARE C., SANNA E., BIGGIO G., LISO G. (2000). Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. CURRENT MEDICINAL CHEMISTRY, vol. 7; p. 249-271.

  7. ALTOMARE C., CELLAMARE S., SUMMO L., CATTO M., CAROTTI A., THULL U., CARRUPT P.-A., TESTA B., STOECKLI-EVANS H. (1998). Inhibition of Monoamine Oxidase-B by Condensed Pyridazines and Pyrimidines: Effects of Lipophilicity and Structure-Activity Relationships. JOURNAL OF MEDICINAL CHEMISTRY, vol. 41; p. 3812-3820.

  8. MCNAUGHT K.ST.P., CARRUPT P.-A., ALTOMARE C., CELLAMARE S., CAROTTI A., TESTA B., JENNER P., MARSDEN C.D. (1998). Isoquinoline derivatives as endogeneous neurotoxins in the aetiology of Parkinson’s diesease.BIOCHEMICAL PHARMACOLOGY, vol. 56; p. 921-933.

  9. TRAPANI G., LATROFA A., FRANCO M., ALTOMARE C., SANNA E., USALA M., BIGGIO G., LISO G. (1998). Propofol analogues. Synthesis, relatioships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors. JOURNAL OF MEDICINAL CHEMISTRY, vol. 41; p. 1846.

  1. ALTOMARE C., CAROTTI A., TRAPANI G., LISO G. (1997). Estimation of Partitioning Parameters of Nonionic Surfactants Using Calculated Descriptors of Molecular Size, Polarity, and Hydrogen Bonding. JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 86; p. 1417.

  2. ALTOMARE C., CELLAMARE S., CAROTTI A., BARRECA M.L., CHIMIRRI A., MONFORTE A.M., GASPARRINI F., VILLANI C., CIRILLI M., MAZZA M. (1996). Substituent effects on the enantioselective retention of anti-HIV 5-aryl-ƒ ́2- 1,2,4-oxadiazolines on R,R-DACH-DNB chiral stationary phase. CHIRALITY, vol. 8; p. 556.

  3. MCNAUGHT K.ST.P., THULL U., CARRUPT P.-A., ALTOMARE C., CELLAMARE S., CAROTTI A., TESTA B., JENNER P., MARSDEN C.D. (1996). Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to MPTP. NEURODEGENERATION, vol. 5; p. 265.

  4. MCNAUGHT K.ST.P., THULL U., CARRUPT P.-A., ALTOMARE C., CELLAMARE S., CAROTTI A., TESTA B., JENNER P., MARSDEN C.D. (1996). Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration. BIOCHEMICAL PHARMACOLOGY, vol. 51; p. 1503.

  5. MCNAUGHT K.ST.P., THULL U., CARRUPT P.-A., ALTOMARE C., CELLAMARE S., CAROTTI A., TESTA B., JENNER P., MARSDEN C.D. (1996). Inhibition of uptake of [3H] dopamine into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. BIOCHEMICAL PHARMACOLOGY, vol. 52; p. 29.

  6. MCNAUGHT K.ST.P., THULL U., CARRUPT P.-A., ALTOMARE C., CELLAMARE S., CAROTTI A., TESTA B., JENNER P., MARSDEN D. (1996). Toxicity to P12 cells of isoquinoline derivatives structurally related to 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine. NEUROSCIENCE LETTERS, vol. 206; p. 37.

  7. ALTOMARE C., CELLAMARE S, CAROTTI A, CASINI G, FERAPPI M, GAVUZZO E, MAZZA F, CARRUPT P.-A, GAILLARD P, TESTA B (1995). X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore. JOURNAL OF MEDICINAL CHEMISTRY, vol. 38; p. 170.

  8. ALTOMARE C., TRAPANI G, FRANCO M, LATROFA A, LISO G (1995). Relationship between hydrophilic-lipophilic balance and behaviour in reversed- phase thin-layer chromatography of some non-ionic surfactants. ACTA TECHNOLOGIAE ET LEGIS MEDICAMENTI, vol. 6; p. 33.

  1. CAROTTI A, ALTOMARE C. (1995). Advanced methodologies in medicinal chemistry research. LA CHIMICA E L'INDUSTRIA, vol. 77; p. 13.

  2. CAROTTI A, ALTOMARE C., CELLAMARE S, MONFORTE A.M, BETTONI G, LOIODICE F, TANGARI N, TORTORELLA V (1995). LFER and CoMFA Studies on Optical Resolution of α-Alkyl-α-Aryloxy Acetic Acid Methyl Esters on DACH-DNB Chiral Stationary Phase. JOURNAL OF COMPUTER- AIDED MOLECULAR DESIGN, vol. 9; p. 131.

  3. KNEUBÜHLER S, THULL U, ALTOMARE C., CARTA V, GAILLARD P, CARRUPT P.-A, CAROTTI A, TESTA B (1995). Inhibition of MAO-B by 5H- indeno[1,2-c]pyridazines: Biological activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR. JOURNAL OF MEDICINAL CHEMISTRY, vol. 38; p. 3874.

  4. MCNAUGHT K.ST.P, THULL U, CARRUPT P.-A, TESTA B, ALTOMARE C., CELLAMARE S, CAROTTI A, JENNER P, MARSDEN C.D (1995). Inhibition of α-Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). NEUROREPORT, vol. 6; p. 1105.

  5. MCNAUGHT K.ST.P, THULL U, CARRUPT P.-A, TESTA B, ALTOMARE C., CELLAMARE S, CAROTTI A, TESTA B, JENNER P, MARSDEN C.D (1995). Inhibition of complex I by isoquinoline derivatives structurally related to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). BIOCHEMICAL PHARMACOLOGY, vol. 50; p. 1903.

  6. THULL U, KNEUBÜHLER S, GAILLARD P, CARRUPT P.-A, TESTA B, ALTOMARE C., CAROTTI A, JENNER P, MCNAUGHT K (1995). Inhibition of monoamine oxidase by isoquinoline derivatives: Qualitative and 3D-quantitative structure-activity relationships. BIOCHEMICAL PHARMACOLOGY, vol. 50; p. 869.

  7. TRAPANI G, ALTOMARE C., FRANCO M, LATROFA A, LISO G (1995). Determination of hydrophile-lipophile balance of some polyethoxylated non- ionic surfactants by reversed-phase thin layer chromatography. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 116; p. 95.

  8. ALTOMARE C., CAMPAGNA F, CARTA V, CELLAMARE S, CAROTTI A, GENCHI G, DE SARRO G (1994). Synthesis, Benzodiazepine Receptor Affinity and Anticonvulsant Activity of 5H-Indeno[1,2-c]pyridazine Derivatives. FARMACO, vol. 49; p. 313.

  9. ALTOMARE C., CAROTTI A, CELLAMARE S, CARRIERI A, CIABATTI R, MALABARBA A (1994). Lipophilicity of Teicoplanin Antibiotics as Assessed by Reversed Phase High Performance Liquid Chromatography. Quantitative Structure-Property and Structure-Activity Relationships. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 46; p. 994.

  1. ALTOMARE C., CELLAMARE S, CAROTTI A, FERAPPI M (1994). Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of RP-8 Stationary Phases for measuring lipophilicity parameters. FARMACO, vol. 49; p. 393.

  2. CARRIERI A, ALTOMARE C., BARRECA M.L, CONTENTO A, CAROTTI A, HANSCH C (1994). Papain Catalyzed Hydrolysis of Aryl Esters: a Comparison of the Hansch, Docking and CoMFA methods. FARMACO, vol. 49; p. 573.

  3. ALTOMARE C., CAROTTI A, CELLAMARE, FANELLI F, GASPARRINI F, VILLANI C, CARRUPT P.-A, TESTA B (1993). Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure- Enantioselective Retention Relationship (QSERR) Study. CHIRALITY, vol. 5; p. 527.

  4. ALTOMARE C., CELLAMARE S, CAROTTI A, FERAPPI M (1993). Linear Solvation Energy Relatioships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters. QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, vol. 12; p. 261.

  5. CAROTTI A, CARTA V, CAMPAGNA F, ALTOMARE C., CASINI G (1993). An Efficient Route to Biologically Active 5H-indeno[1,2-c]pyridazin-5-ones. FARMACO, vol. 48; p. 137.

  6. KNEUBÜHLER S, CARTA V, ALTOMARE C., CAROTTI A, TESTA B (1993). Synthesis and Monoamine Oxidase Inhibitory Activity of 3-Substituted 5H- Indeno[1,2-c]pyridazines. HELVETICA CHIMICA ACTA, vol. 76; p. 1956.

  7. ALTOMARE C., CAROTTI A, CASINI G, CELLAMARE S, FERAPPI M, VITALI C (1992). Structure-Antimicrobial Activity Relationships of Quaternary Ammonium Derivatives of Perhydropyrrolo[3,4-c] pyridine. ARZNEIMITTEL- FORSCHUNG, vol. 42(I); p. 152.

  8. ALTOMARE C., CAROTTI A, CELLAMARE S, CONTENTO A, CIABATTI R, MALABARBA A, BERT M, GOLDSTEIN B (1992). QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity. MEDICINAL CHEMISTRY RESEARCH, vol. 1; p. 393.

  9. ALTOMARE C., CARRUPT P.-A, GAILLARD P, EL TAYAR N, TESTA B, CAROTTI A (1992). Quantitative Structure-Metabolism Relationship Analyses of MAO-mediated Toxication of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Analogues. CHEMICAL RESEARCH IN TOXICOLOGY, vol. 5; p. 366.

  1. ALTOMARE C., CARRUPT P.A, EL TAYAR N, TESTA B, NAGATSU T (1991). Electronic and Conformational Effects on the Lipophilicity of Isomers and Analogs of the Neurotoxin 1-methyl-4-phenylpyridinium MPPT). HELVETICA CHIMICA ACTA, vol. 74; p. 290.

  2. ALTOMARE C., TSAI R.S, EL TAYAR N, TESTA B, CAROTTI A, CELLAMARE S, DE BENEDETTI P.G (1991). Determination of Lipophilicity and Hydrogen- bond Donor Acidity of Bioactive Sulponyl-containing Compounds by Reversed- phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-Activity Relations. JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 43; p. 191.

  3. EL TAYAR N, TSAI R.S, VALLAT P, ALTOMARE C., TESTA B (1991). Measurements of Partition Coefficients by Various Centrifugal Partition Chromatographic T echniques: A Comparative Evaluation. JOURNA L OF CHROMATOGRAPHY, vol. 556; p. 181.

  4. ALTOMARE C., CAROTTI A, CASINI G, CELLAMARE S, FERAPPI M, SIRO BRIGIANI G, PERSICHELLA M (1990). Synthesis and Pharmacological Evaluation of Perhydropyrrolo[3,4-c]pyridine Derivatives. FARMACO, vol. 45; p. 489.

  5. ALTOMARE C., CAROTTI A, CELLAMARE S, LEOGRANDE G, DE VITO D (1990). Determination of Antitubercular Drugs in Human Plasma by HPLC Through Direct Injection. FARMACO, vol. 45; p. 1229.

  6. ALTOMARE C., CAROTTI A, CELLAMARE S, FERAPPI M (1989). Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 56; p. 273.

  7. ALTOMARE C., CAROTTI A, CASINI G, CELLAMARE S, FERAPPI M, GAVUZZO E, MAZZA F, PANTALEONI G, GIORGI R (1988). Synthesis and Cognition Activating Properties of Some Mono- and Bicyclic Dilactam Derivatives. JOURNAL OF MEDICINAL CHEMISTRY, vol. 31; p. 2153.

  8. ALTOMARE C., CAROTTI A, CELLAMARE S, FERAPPI M (1988). Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale. LA CHIMICA E L'INDUSTRIA, vol. 70; p. 100.

  9. ALTOMARE C., CAROTTI A, CELLAMARE S, FERAPPI M, CAGIANO R, RENNA G (1988). QSAR Analysis of Chemical and Serum-catalyzed Hydrolysis of Phenyl Esters Prodrugs of Nipecotic Acid. INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 48; p. 91.

  10. ALTOMARE C., CAROTTI A, CELLAMARE S, FERAPPI M (1987). L’IRSP nella determinazione di aril-nipecotati in siero. BOLLETTINO CHIMICO FARMACEUTICO, vol. 10; p. 430.

  1. CAMPAGNA F, ALTOMARE C., CAROTTI A, CASINI G, FERAPPI M (1986). Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids. STEROIDS, vol. 47; p. 307.

  2. ALTOMARE C., CAMPAGNA F, CAROTTI A, STEINMETZ W.E (1985). On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids. HETEROCYCLES, vol. 23; p. 1933.

  3. ALTOMARE C., CAROTTI A, CASINI G, FERAPPI M (1984). ). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 21; p. 777.

  4. ALTOMARE C., CAMPAGNA F, CAROTTI A, CASINI G (1983). Sintesi di sistemi eterociclici a potenziale attività farmacologica contenenti un nucleo 1,3- ossazinico. LA CHIMICA E L'INDUSTRIA, vol. 65; p. 120.

  5. ALTOMARE C., CAROTTI A, CAMPAGNA F (1983). Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 20; p. 1751.

Articles and chapters in books

  1. TOGO M.V., MASTROLORITO F., GAMBACORTA N., TRISCIUZZI D., TONDO A.R., CUTROPIA F., BELGIOVINE V., ALTOMARE C.D., AMOROSO N., NICOLOTTI O. (2025). TIRESIA and TISBE: Explainable Artificial Intelligence Based Web Platforms for the Transparent Assessment of the Developmental Toxicity of Chemicals and Drugs. In: Nicolotti, O. (eds) Computational Toxicology. Methods in Molecular Biology, vol 2834. Humana, New York, NY.

  2. CIRIACO F., GAMBACORTA N., LEONETTI F., ALTOMARE C.D., NICOLOTTI O. (2023). Virtual Reverse Screening Approach to Target Type 2 Cannabinoid Receptor. METHODS IN MOLECULAR BIOLOGY, 2576, pp. 495-504.

  3. PISANI L., DE CANDIA M., RULLO M., ALTOMARE C.D. (2023). Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology. METHODS IN MOLECULAR BIOLOGY, 2558, pp. 207-220.

  4. GAMBACORTA N., TRISCIUZZI D., CIRIACO F., MASTROLORITO F., TOGO M.V., TONDO A.R., ALTOMARE C.D., AMOROSO N., NICOLOTTI O. (2023). Chapter 26 - Machine learning resources for drug design. In Roy K. (Ed.): Cheminformatics, QSAR and Machine Learning Applications for Novel Drug Development, Academic Press, 2023, pp. 663-678, ISBN 9780443186387.

  5. DE CANDIA M., DENORA N., ALTOMARE C.D. (2016). Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events, in Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals (eds C. Lamberth and J. Dinges), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527693931.ch5

  1. ZAHARIA C.A., CELLAMARE S., ALTOMARE, C.D. (2016) Oxazolidinone Amide Antibiotics, in Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals (eds C. Lamberth and J. Dinges), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527693931.ch11

  2. DE CANDIA M., ALTOMARE C.D. (2015). Organofluorine-containing therapeutics for treatment of cardiovascular disease. In Westwell A.D. (Ed.) Fluorinated Pharmaceuticals: Advances in Medicinal Chemistry, Future Science Ltd (London, UK), p. 107-126.

  3. ALTOMARE C. (1995). Comparative Molecular Field Analysis (CoMFA). In: G. BOLIS, M. BOTTA, A. MARTINELLI (Eds). Approaches to Structure-Property Relationships. p. 163-172, SIENA: Tipografia Senese

  4. ALTOMARE C., CAROTTI A, CARTA V, KNEUBÜHLER S, CARRUPT P.-A, TESTA B (1995). Modeling of new pyridazine inhibitors of MAO-B using QSAR and CoMFA approaches. In: F. SANZ, J. GIRALDO F. MANAUT, EDS.. QSAR and Molecular Modelling: Concepts, Computational Tools and Biological Applications. p. 463, BARCELONA: Prous Science

  5. ALTOMARE C., CAROTTI A, CELLAMARE S, CARRUPT P.-A, TESTA B (1993). Partitioning behaviour of piracetam-type cognition enhancers. In: C.G. WERMUTH, ED. Trends in QSAR and Molecular Modelling 92. p. 532, LEIDEN: ESCOM

  6. B, EL TAYAR N, ALTOMARE C., CARRUPT P.-A, TSAI R.-S (1993). Lipophilicity and Hydrogen Bonding Capacity: their Role in Drug Binding and Disposition. In: J.-P. TILLEMENT, H. ECKERT, E. ALBENGRES, J. BARR, P. BAUMANN, F. BELPAIRE AND M. LEMAIRE, EDS.. Proceedings of International Symposium on "Blood Binding and Drug Transfer". p. 110-120, PARIS: Fort et Clair

  7. TESTA B, EL TAYAR N, ALTOMARE C., CARRUPT P.-A, TSAI R.-S, CAROTTI A (1992). The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics. In: P. ANGELI, U. GULINI AND W. QUAGLIA, EDS.. Trends in Receptor Research, Pharmacochemistry Library. vol. 18, p. 61, AMSTERDAM: Elsevier

  8. ALTOMARE C., TSAI R.-S, EL TAYAR N, TESTA B, CARRUPT P.-A, CAROTTI A, DE BENEDETTI P.G (1991). Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC. In: C. SILIPO AND A. VITTORIA, EDS.. QSAR: Rational Approaches to the Design of Bioactive Compounds, Pharmacochemistry Library. vol. 16, p. 139, AMSTERDAM: Elsevier

  9. ALTOMARE C., CAROTTI A, CELLAMARE S, FERAPPI M (1989). Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships. QSAR: Quantitative Structure Activity Relationships in Drug Design. Progress in Clinical and Biological Research. vol. 291, p. 79, NEW YORK: Alan R.Liss, Inc.

Patents

  1. ORLANDO M., HEMBERGER J., TRAPANI G., LISO G., ALTOMARE C., LATROFA A., BIGGIO G., SERRA M., SANNA E., LAQUINTANA V. (2004). Water-soluble Prodrugs of Propofol. USP Patent WO2004/033424 A1

  2. TRAPANI G., ALTOMARE C., LISO G., LATROFA A., BIGIO G., SERRA M., SANNA E., BIOTECNOLOGIE GES MITTELHESSE MBH DE (2004). Water- soluble Prodrugs of Propofol. German Patent DE20215415U

  3. DENORA N., LOPALCO A., FRANCO M., LOPEDOTA A.A., LAQUINTANA V., CUTRIGNELLI A., LA FORGIA R., GHAFIR EL IDRISSI I., COPPA A., IACOBAZZI R.M., ALTOMARE C.D. (2022). Cold kits based on PSMA ligands for the preparation of radiopharmaceuticals. WO2022144764

Bari, 12/10/2024

pubblicato il 25/07/2013 — ultima modifica 15/10/2024

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